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MPTP损伤的小鼠PD模型的制作与评价
引用本文:许耀刚,庞晓峰,汲娟娟.MPTP损伤的小鼠PD模型的制作与评价[J].生物化学与生物物理进展,2006,33(10):1014-1018.
作者姓名:许耀刚  庞晓峰  汲娟娟
作者单位:1. 电子科技大学生命科学与技术学院,成都,610054;中国科学院生物物理研究所,脑与认知国家重点实验室,北京,100101
2. 电子科技大学生命科学与技术学院,成都,610054
3. 中国科学院生物物理研究所,脑与认知国家重点实验室,北京,100101
摘    要:帕金森病(Parkinson!sdisease,PD)动物模型研究的目的是揭示多巴胺能神经元特异性损伤的机制,进而探索针对这种损伤的神经保护方法或治疗方法.由神经毒素MPTP损伤的小鼠PD模型,广泛应用于散发性PD的研究中.根据注射总剂量、两次注射间隔时间、注射方式的不同,制成了适合于不同研究目的的各种小鼠PD模型.关于MPTP导致的PD模型动物神经损伤的评价方式也是多层面、多指标并存的.对MPTP动物模型的起源和MPTP导致多巴胺能神经元损伤途径进行了较为系统的概述,并对MPTP小鼠PD模型的制作方法与评价指标进行较为详细的归纳.

关 键 词:帕金森病(PD)  MPTP  小鼠  模型
收稿时间:6/19/2006 4:23:40 PM
修稿时间:8/3/2006 9:45:15 PM

The Creation and Assessment of MPTP-Lesioned Model of PD in Mice
XU Yao-Gang,PANG Xiao-Feng and JI Juan-Juan.The Creation and Assessment of MPTP-Lesioned Model of PD in Mice[J].Progress In Biochemistry and Biophysics,2006,33(10):1014-1018.
Authors:XU Yao-Gang  PANG Xiao-Feng and JI Juan-Juan
Institution:Department of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China;State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Department of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China;State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China
Abstract:The aim of studying on animal model of Parkinson's Disease (PD) is to discover the mechanism underlying the specific lesion of the dopaminergic neurons, then to seek out protective ways or therapies against the lesion. The mouse model of PD induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrapyridine (MPTP) is applied extensively in the studies of the sporadic PD. Based on differences in the total amount of MPTP administrated, time between injections, and the injection style (intraperitoneally versus subcutaneously), various models of PD, which could satisfy many different studies, have been created. The assessment of the MPTP lesion is multilevel and contains a series of parameters. The origin of MPTP-lesioned model of PD and the pathways of MPTP causing lesions to dopaminergic neurons were systematically illuminated, then the creation and assessment of MPTP-lesioned PD model was elaborated.
Keywords:Parkinson's disease  MPTP  mouse  model  
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