| 与学习记忆相关的睡眠新功能——突触稳态 |
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| 引用本文： | 李洋,陈芳,胡志安.与学习记忆相关的睡眠新功能——突触稳态[J].生物化学与生物物理进展,2009,36(3):269-273. |
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| 作者姓名： | 李洋 陈芳 胡志安 |
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| 作者单位： | 第三军医大学生理教研室,重庆,400038 |
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| 基金项目： | 国家自然科学基金资助项目(30870817, 30670668). |
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| 摘 要： | 近年来的许多研究证实睡眠有利于学习和记忆．不但学习后的睡眠具有记忆巩固功能，而且学习前的睡眠对于随后的学习也是必需的．长时间觉醒学习后脑内突触连接增多、增强，导致突触空间饱和，阻碍随后继续学习．睡眠的作用是减弱突触连接到基础水平，为随后的学习记忆提供充足的空间和能量．
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| 关 键 词： | 睡眠 慢波活动 突触稳态 突触权重 可塑性 学习记忆 |
| 收稿时间： | 2008/6/19 0:00:00 |
| 修稿时间： | 2008/11/4 0:00:00 |
Weakening Synapse to Baseline During Sleep |
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| LI Yang,CHEN Fang and HU Zhi-An.Weakening Synapse to Baseline During Sleep[J].Progress In Biochemistry and Biophysics,2009,36(3):269-273. |
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| Authors: | LI Yang CHEN Fang and HU Zhi-An |
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| Institution: | Department of Physiology, Third Military Medical University, Chongqing 400038, China;Department of Physiology, Third Military Medical University, Chongqing 400038, China;Department of Physiology, Third Military Medical University, Chongqing 400038, China |
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| Abstract: | It is well believed that learning and memory is one of the functions of sleep. Not only does the sleep after learning aid memory consolidation, but enough sleep before learning is necessary for memory formation. Due to the net increase in synaptic strength, waking plasticity has a cost in terms of energy requirements, space requirements, and progressively saturates the capacity to learning. The review will focus on the role of sleep which is to downscale synaptic strength to a baseline level that is beneficial for learning and memory. |
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| Keywords: | sleep SWA synaptic homeostasis synaptic weight plasticity learning and memory |
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