| 哺乳动物性别决定和性反转 |
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| 引用本文： | 徐晋麟,徐沫.哺乳动物性别决定和性反转[J].生物化学与生物物理进展,1998,25(1):30-36. |
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| 作者姓名： | 徐晋麟 徐沫 |
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| 作者单位： | 上海交通大学生物科学与技术系，上海 200240;浙江大学高分子系，杭州 310027 |
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| 基金项目： | 国家自然科学基金资助项目(39370551). |
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| 摘 要： | 目前已知SRY仅是涉及性别决定过程的基因之一.近年来又发现和克隆了许多可能参与性腺分化与发育的基因，如副中肾抑制基因MIS，也称抗副中肾激素基因AMH；SRY相关基因SOX9；编码甾类因子的基因SFI；X-连锁的DAX基因；Wilm′s肿瘤抑制基因WTI；以及X-连锁的剂量敏感基因DSS等，并新建立了性别决定的Z-基因模型，DSS-基因模型和Jimenez等的模型，较合理地解释了哺乳动物性别决定的分子机理和以前难以解释的各种奇特的性反转现象，使性别决定的研究取得了长足的进展，但仍有一些悬而未决的问题有待于进一步探索.
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| 关 键 词： | 性别决定，性反转，SRY/Sry，哺乳动物，Z-基因模型，DSS-基因模型 |
| 收稿时间： | 1996/11/6 0:00:00 |
| 修稿时间： | 4/2/1997 12:00:00 AM |
Sex Determination and Sex Reversal of Mammalian |
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| XU Jin-lin and XU Mo.Sex Determination and Sex Reversal of Mammalian[J].Progress In Biochemistry and Biophysics,1998,25(1):30-36. |
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| Authors: | XU Jin-lin and XU Mo |
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| Institution: | Department of Biological Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China;Department of Macromolecule, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | SRY is the only gene currently known to be involved in the process of sex determination. A number of cloned genes probably participate in gonadal development: the MIS (also called AMH), the SOX9, the SF1, the DAX1, the WT1 and the DSS etc. Some gene model for mammalian sex determination such as Z-gene model and DSS-gene model etc. have recently been proposed. Those models provide a rational explanation not only for the cases of XX and XY sex reversal currently known to occur in humans and other mammals,but also for molecular mechanism of sex determination. Many questions of mammalian sex determination still remain unresolved. The identification and functional analysis of other genes in the mammalian sex determining cascade will determine the validity of this hypothesis. |
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| Keywords: | sex determination sex reversal SRY/Sry Z-gene model DSS-gene model |
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