生长激素分泌促进剂及构效关系研究进展

生长激素分泌促进剂是一类作用于垂体和下丘脑的具有专一性促生长激素释放作用的寡肽及其类似物.由于其分子质量小、活性高、可口服、作用专一而有可能成为新的生长激素治疗药物.目前已经发展了很多具有此类活性的多种结构的化合物,如肽、环肽、肽醇及非肽类似物等.尽管这类化合物的作用机制尚未完全明确,但已有证据表明存在新的调节生长激素分泌的途径和新的调节因子.

Growth Hormone Secretagogues and Their Structure-activity Relationship

Growth hormone(GH) secretagogues are synthetic oligopeptides and their non-peptide mimetics which act on the pituitary and the hypothalamus to stimulate GH release. Because of their small molecular weight, high potency, oral activity and specific action, GH secretagogues can act as new agents in GH treatment. Active compounds with diverse structure, such as peptides, cyclic peptides, peptide alcohols and non-peptide mimetics have been found. Although the exact mode of action of these agents has not been fully established, they may be mimeticking a new endogenous GH-releasing factor in a new pathway for the control of the release of GH.