| 腺病毒载体有效性和安全性的改进 |
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| 引用本文： | 刘雪丰,张连峰,王丽华,蔡有余.腺病毒载体有效性和安全性的改进[J].生物化学与生物物理进展,1998,25(4):304-307. |
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| 作者姓名： | 刘雪丰 张连峰 王丽华 蔡有余 |
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| 作者单位： | 中国医学科学院中国协和医科大学实验动物研究所，北京 100021;中国医学科学院中国协和医科大学实验动物研究所，北京 100021;中国医学科学院中国协和医科大学实验动物研究所，北京 100021;中国医学科学院中国协和医科大学实验动物研究所，北京 100021 |
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| 基金项目： | 卫生部基金资助项目(94-1-050). |
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| 摘 要： | 论述了如何改进腺病毒载体以提高其有效性和安全性.腺病毒载体是将基因转移到体内多种不同细胞的有效运载工具.第一代腺病毒载体已证明在基因治疗中有很好的前途, 虽然它在有效性和安全性方面还存在不足之处,但这些局限正在被逐步克服.
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| 关 键 词： | 腺病毒载体 安全性 有效性 |
| 收稿时间： | 1997/4/14 0:00:00 |
| 修稿时间： | 1997/7/17 0:00:00 |
The Improvements of Adenovirus Vectors in Efficacy and Safety |
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| LIU Xue-feng,ZHANG Lian-feng,WANG Li-hua and CAI You-yu.The Improvements of Adenovirus Vectors in Efficacy and Safety[J].Progress In Biochemistry and Biophysics,1998,25(4):304-307. |
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| Authors: | LIU Xue-feng ZHANG Lian-feng WANG Li-hua and CAI You-yu |
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| Institution: | Instituite of Laboratory Animal Science,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China;Instituite of Laboratory Animal Science,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China;Instituite of Laboratory Animal Science,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China;Instituite of Laboratory Animal Science,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100021, China |
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| Abstract: | Adenoviruses are efficient gene transfer vectors for variety of cell types in vivo. The first-generation recombinant adenoviruses that lack E1 sequences have shown tremendous promise in animal and human models of gene therapy. Having some limitations at aspect of efficacy and safety,the adenovirus vectors are being gradually improved to resolve these problems. The developments of construction of adenovirus vectors in increasing the efficacy and safety was described. |
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| Keywords: | adenovirus vector safety efficacy |
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