| 大鼠成骨细胞在聚乳酸、马来酸酐改性聚乳酸表面的粘附性能研究 |
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| 引用本文： | 潘君,王远亮,曹雪波,苏兰,秦建,卢晓,蔡绍皙.大鼠成骨细胞在聚乳酸、马来酸酐改性聚乳酸表面的粘附性能研究[J].生物化学与生物物理进展,2001,28(5):688-690. |
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| 作者姓名： | 潘君 王远亮 曹雪波 苏兰 秦建 卢晓 蔡绍皙 |
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| 作者单位： | 重庆大学生物工程学院生物力学与组织工程教育部重点实验室重庆400044 |
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| 基金项目： | 国家自然科学基金资助项目（19732003、19872080）和教育部重点科技资助项目. |
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| 摘 要： | 采用微管吸吮装置对大鼠成骨细胞,在聚乳酸和马来酸酐改性聚乳酸材料表面的粘附性能进行了研究.目的是评价材料的粘附性能和改性方法，并筛选材料.研究表明：与玻璃材料相比，成骨细胞在聚乳酸表面的粘附力更大，经化学结构改性后，聚乳酸对成骨细胞24 h的粘附性能提高了近2倍.成骨细胞在改性聚乳酸材料表面的24 h组的粘附力是15 min组的1.3倍（测量时间为3 h），而在聚乳酸上则差别不明显.实验证实，改性聚乳酸是一种更利于成骨细胞粘附的支撑材料，采用的改性方法可行.
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| 关 键 词： | 聚乳酸，改性，成骨细胞，粘附性能 |
| 收稿时间： | 2000/10/18 0:00:00 |
| 修稿时间： | 2000年10月18 |
Study of Adhesion Property of Wistar Rat Osteoblasts on Polylactide and Maleic Anhydride Modified-Polylactide |
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| PAN Jun,WANG Yuan-Liang,CAO Xue-Bo,SU Lan,QIN Jian,LU Xiao and CAI Shao-Ji.Study of Adhesion Property of Wistar Rat Osteoblasts on Polylactide and Maleic Anhydride Modified-Polylactide[J].Progress In Biochemistry and Biophysics,2001,28(5):688-690. |
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| Authors: | PAN Jun WANG Yuan-Liang CAO Xue-Bo SU Lan QIN Jian LU Xiao and CAI Shao-Ji |
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| Institution: | Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China;Biological Engineering College, Key Laboratory for Biomechanics & Tissue Engineering of the Education Ministry of China, Chongqing University, Chongqing 400044, China |
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| Abstract: | Micropipette-aspiring system was selected to test the adhesion property of Wistar rat osteoblasts on polylactide (PLA) and maleic anhydride modified-polylactide (MPLA) made in our laboratory. The aims were evaluating one of the material's suitability for tissue engineering-adhesion property and the modification method. The results showed that osteoblasts had better adhesion property on PLA than on glass. The adhesion force of osteoblasts on PLA at 24 hour increased about 2 times after modification. The 24 hour adhesion force of osteoblasts on MPLA was 1.3 times more than that of 15 minute. But there was no significant difference on PLA. The research demonstrates that MPLA is a better scaffold for osteoblasts adhesion and the modification method is suitable for tissue engineering. |
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| Keywords: | polylactide modification osteoblast adhesion property |
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