| 酸敏感离子通道的功能及其相关调控 |
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| 引用本文： | 伍龙军,徐天乐.酸敏感离子通道的功能及其相关调控[J].生物化学与生物物理进展,2003,30(3):339-343. |
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| 作者姓名： | 伍龙军 徐天乐 |
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| 作者单位： | 中国科学技术大学神经生物学与生物物理学系,合肥,230027 |
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| 基金项目： | 国家杰出青年基金（30125015）, 教育部跨世纪优秀人才基金, 国家重点基础研究发展规划项目（973）（G1999054000）和中国科学院“百人计划”资助项目. |
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| 摘 要： | 酸敏感离子通道（ASICs）是一类由胞外酸化所激活的阳离子通道.目前，已发现了6个ASICs亚基，它们在外周和中枢神经系统中广泛表达.利用基因敲除等技术，已证明它们在触觉、痛觉、酸味觉以及学习记忆中具有重要作用.同时，它们也参与某些病理反应.ASICs可以被神经肽、温度、金属离子和缺血相关物质等调控，从而整合细胞周围的多种信号以行使其功能.
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| 关 键 词： | 酸敏感离子通道（ASICs），功能，调控 |
| 收稿时间： | 2002/11/12 0:00:00 |
| 修稿时间： | 2002年11月12 |
The Functions of Acid-sensing Ion Channels and Their Modulations |
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| WU Long-Jun and XU Tian-Le.The Functions of Acid-sensing Ion Channels and Their Modulations[J].Progress In Biochemistry and Biophysics,2003,30(3):339-343. |
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| Authors: | WU Long-Jun and XU Tian-Le |
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| Institution: | Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China;Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China |
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| Abstract: | Acid-sensing ion channels (ASICs) are ligand-gated ion channels activated by extracellular proton. To date, six members of ASICs family have been identified. They are widely expressed in the peripheral and central nervous system. Using gene knockout techniques, ASICs are demonstrated to be involved in sensory perception as touch, pain, sour taste, learning and memory as well as some pathological conditions. ASICs can be modulated by neuropeptide, temperature, some metal ions and ischemia-related compounds, integrating multiple extracellular signals to function their roles. |
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| Keywords: | acid-sensing ion channels (ASICs) function modulation |
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