| 硒结合蛋白1的生物功能及其与疾病的关系 |
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| 引用本文： | 贾义,代杰,张亮亮,夏欢.硒结合蛋白1的生物功能及其与疾病的关系[J].生物化学与生物物理进展,2019,46(2):128-137. |
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| 作者姓名： | 贾义 代杰 张亮亮 夏欢 |
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| 作者单位： | 贵州医科大学化学生物学教研室，贵阳 550025,贵州医科大学化学生物学教研室，贵阳 550025,贵州医科大学化学生物学教研室，贵阳 550025,贵州医科大学化学生物学教研室，贵阳 550025 |
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| 基金项目： | 国家自然科学基金（21561006, 21867007），贵州省科学技术基金（LH[2016]7372）和贵州省细胞与基因工程创新群体重大研究项目(KY[2016]031)资助. |
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| 摘 要： | 硒结合蛋白1 (SELENBP1)是1989年发现的定位于细胞质和细胞核的一种结合硒原子的含硒蛋白质.以往的研究表明,SELENBP1在高尔基体中蛋白质的转运、泛素化/去泛素化介导的蛋白质降解、硫代谢、调节缺氧诱导因子的稳定性等方面发挥着重要作用.也与口臭、癌症、精神分裂症和肾损伤等疾病的发生发展密切相关.本文对SELENBP1的生物功能及其与疾病关系的最新研究进展进行了综述和展望.
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| 关 键 词： | 生物无机化学 硒结合蛋白1 蛋白质转运和降解 硫代谢 口臭 癌症 |
| 收稿时间： | 2018/8/31 0:00:00 |
| 修稿时间： | 2018/10/31 0:00:00 |
Biological Functions of Selenium-binding Protein 1and Its Relationship With Diseases |
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| JIA Yi,DAI Jie,ZHANG Liang-Liang and XIA Huan.Biological Functions of Selenium-binding Protein 1and Its Relationship With Diseases[J].Progress In Biochemistry and Biophysics,2019,46(2):128-137. |
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| Authors: | JIA Yi DAI Jie ZHANG Liang-Liang and XIA Huan |
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| Institution: | Department of Chemical Biology, Guizhou Medical University, Guiyang 550025, China,Department of Chemical Biology, Guizhou Medical University, Guiyang 550025, China,Department of Chemical Biology, Guizhou Medical University, Guiyang 550025, China,Department of Chemical Biology, Guizhou Medical University, Guiyang 550025, China |
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| Abstract: | Selenium-binding protein 1 (SELENBP1) is a selenium-containing protein localized in the cytoplasm and nucleus discovered in 1989. Previous studies have shown that SELENBP1 plays an important role in protein transport in Golgi, ubiquitination/deubiquitination-mediated protein degradation, sulfur metabolism, and regulation the stability of hypoxia-inducible factor (HIF). It is also closely related to the development of diseases such as halitosis, cancer, schizophrenia and kidney damage. In this paper, the recent research progress on the biological function of SELENBP1 and its relationship with disease is reviewed and prospected. |
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| Keywords: | bioinorganic chemistry selenium-binding protein 1 protein transport and degradation sulfur metabolism halitosis cancer |
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