| 细菌表面展示技术研究新进展 |
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| 引用本文： | 向红英,王菊芳,杨愈丰,吕延成.细菌表面展示技术研究新进展[J].生物化学与生物物理进展,2019,46(2):162-168. |
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| 作者姓名： | 向红英 王菊芳 杨愈丰 吕延成 |
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| 作者单位： | 遵义医科大学珠海校区，珠海 519040;珠海市中药基础与应用研究重点实验室，珠海 519040,广东省发酵与酶工程重点实验室（华南理工大学生物科学与工程学院），广州 510640,遵义医科大学珠海校区，珠海 519040;珠海市中药基础与应用研究重点实验室，珠海 519040,遵义医科大学珠海校区，珠海 519040 |
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| 基金项目： | 国家自然科学基金资助项目（31560244），贵州省科技合作计划项目（黔科合LH字[2015]7547），遵义市“15851人才精英工程”科研项目，珠海市重要基础与应用研究重点实验室开放课题（ZYKL-2016K2），广东省发酵与酶工程重点实验室（华南理工大学生物科学与工程学院）开放基金资助项目（FJ2015003），遵义医科大学研究生科研基金立项课题(ZYK009)资助. |
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| 摘 要： | 细菌表面展示是将靶标蛋白质表达于细菌表面以更好地实现其功能的一种技术,它在重组细菌疫苗、生物燃料电池、全细胞催化剂和生物修复等多个领域均有广泛的应用.随着相关技术的发展,表面展示系统的各种性能被不断地改良,同时新的表面展示系统也陆续被开发和应用,使该技术得到持续的丰富和发展.本文重点关注近年研究得较多的细菌表面展示系统,主要对各类细菌表面展示系统的开发、改造和修饰,以及该技术在生物修复和生物传感器方面的应用作一综述.
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| 关 键 词： | 细菌表面展示系统 载体蛋白 冰核蛋白 生物修复 生物传感器 |
| 收稿时间： | 2018/6/28 0:00:00 |
| 修稿时间： | 2018/10/24 0:00:00 |
The Research Progress of Bacterial Surface Display Technology |
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| XIANG Hong-Ying,WANG Ju-Fang,YANG Yu-Feng and LV Yan-Cheng.The Research Progress of Bacterial Surface Display Technology[J].Progress In Biochemistry and Biophysics,2019,46(2):162-168. |
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| Authors: | XIANG Hong-Ying WANG Ju-Fang YANG Yu-Feng and LV Yan-Cheng |
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| Institution: | Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China;Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China,Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510640, China,Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China;Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China,Zhuhai Campus of Zunyi Medical University, Zhuhai 519040, China |
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| Abstract: | Bacterial surface display is a kind of technology to express target protein on the surface of bacteria, so as to exert its function preferably. It has been widely applied in many fields such as recombinant bacteria vaccine, biofuel cell, whole cell catalyst and bioremediation. With the development of numerous related technologies, the performance of surface display system has been continuously improving. At the same time, several new surface display systems have also been developed and applied, all of which accelerate the multiformity and perfection of this technology continuously. This paper focus on the progress of bacterial surface display systems, mainly on their development, modification and improvement, as well as their application on bioremediation and biosensor. |
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| Keywords: | bacterial surface display system carrier protein ice nucleation protein bioremediation biosensor |
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