| 基于Web的基因组浏览器研究现状 |
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| 引用本文： | 张海川,李杰,王亚东.基于Web的基因组浏览器研究现状[J].生物化学与生物物理进展,2014,41(11):1182-1190. |
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| 作者姓名： | 张海川 李杰 王亚东 |
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| 作者单位： | 哈尔滨工业大学计算机科学与技术学院,哈尔滨工业大学计算机科学与技术学院,哈尔滨工业大学计算机科学与技术学院 |
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| 基金项目： | 863基金(2012AA02A604), 国家自然科学基金(61173085), 黑龙江省博士后基金(LBH-Q13084)资助项目 |
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| 摘 要： | 测序技术的发展促使人类基因组测序成本急剧降低,测序速度迅速增加,对这些数据的分析和可视化已成为生命科学领域最重要的课题之一.基因组浏览器技术在基因序列分析,遗传密码解读,复杂疾病研究等方面具有重要意义.本文综述了9种主要的基因组浏览器技术,并从可视化内容、可视化形式、软件系统架构等角度分析了它们的特点.最后,探讨了基因组浏览器发展所面临的挑战.
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| 关 键 词： | 基因组浏览器 可视化 基因组测序 |
| 收稿时间： | 3/1/2014 12:00:00 AM |
| 修稿时间： | 2014/5/29 0:00:00 |
Research on web-based genome browser technology |
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| ZHANG Hai-chuan,LI Jie and WANG Ya-Dong.Research on web-based genome browser technology[J].Progress In Biochemistry and Biophysics,2014,41(11):1182-1190. |
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| Authors: | ZHANG Hai-chuan LI Jie and WANG Ya-Dong |
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| Institution: | School of Computer Science and Technology, Harbin Institute of Technology,School of Computer Science and Technology, Harbin Institute of Technology,School of Computer Science and Technology, Harbin Institute of Technology |
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| Abstract: | Advances in sequencing technology have led to a sharp decrease in the cost and rapid increase in the speed of sequencing an entire human genome. It has become one of the most important issues to analyze and visualize genome sequence in life science field. Genome browser technology plays important roles in analyzing genome sequence, interpreting genetic codes, studying complex diseases and so on. In this paper, we review the nine major genome browser technologies and analyze their characteristics in visualized content, visible form, software system architecture and so on. Finally, we discuss the challenges that genome browser faced. |
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| Keywords: | genome browser visualization genome sequencing |
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