| 酸敏感离子通道研究进展 |
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| 引用本文： | 伍龙军,徐天乐.酸敏感离子通道研究进展[J].生物化学与生物物理进展,2002,29(2):197-201. |
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| 作者姓名： | 伍龙军 徐天乐 |
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| 作者单位： | 中国科学技术大学神经生物学与生物物理学系,合肥,230027 |
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| 基金项目： | 国家杰出青年基金(30125015)、教育部跨世纪优秀人才基金、科技部973项目(G1999054000)和中国科学院“百人计划”资助. |
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| 摘 要： | 组织酸化是生理和病理下常见的现象.神经元可以通过酸敏感的离子通道（ASICs）来感受细胞周围的pH值的降低.ASICs属于NaC/DEG家族的一个成员.目前，已发现了6个ASICs亚基，它们在外周和中枢神经系统中广泛表达，其同聚体和异聚体通道有着各种不同的电生理学特性.ASICs在机体感觉尤其是痛觉中起着至关重要的作用.
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| 关 键 词： | 组织酸化，酸敏感离子通道（ASICs），痛觉 |
| 收稿时间： | 2001/9/13 0:00:00 |
| 修稿时间： | 2001年9月13日 |
Progress in Acid-sensing Ion Channels |
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| WU Long-Jun and XU Tian-Le.Progress in Acid-sensing Ion Channels[J].Progress In Biochemistry and Biophysics,2002,29(2):197-201. |
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| Authors: | WU Long-Jun and XU Tian-Le |
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| Institution: | Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China;Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China |
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| Abstract: | Tissue acidosis is a general phenomenon under physiological and pathological conditions. Through acid-sensing ion channels (ASICs), neuron can detect the drops in extracellular pH. ASICs are one of members of DEG/ENaC family. To date, six subunits of ASICs family have been identified. They are widely expressed in the peripheral and central nervous system. The homomers and heteromers channels of these subunits exhibit a variety of electrophysiological properties. ASICs play a critical role in several modalities of sensation, especially nociception. |
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| Keywords: | tissue acidosis acid-sensing ion channels (ASICs) nociception |
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