| 谷胱甘肽硫转移酶基因表达的调控 |
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| 引用本文： | 庞战军,陈瑗,周玫.谷胱甘肽硫转移酶基因表达的调控[J].生物化学与生物物理进展,1997,24(5):401-405. |
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| 作者姓名： | 庞战军 陈瑗 周玫 |
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| 作者单位： | 第一军医大学自由基医学研究室，广州 510515;第一军医大学自由基医学研究室，广州 510515;第一军医大学自由基医学研究室，广州 510515 |
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| 基金项目： | 国家自然科学基金资助项目(39670197). |
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| 摘 要： | 催化内源性或外源性亲电子化合物与谷胱甘肽(GSH)结合的谷胱甘肽硫转移酶(GST)超基因家族是一族解毒功能蛋白.其基因的表达通过不同的机制受多种物质的调控.根据最近文献资料,对调控谷胱甘肽硫转移酶基因表达的基因结构、调控机制及氧化应激对谷胱甘肽硫转移酶基因表达的调控作用等作一简要综述.
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| 关 键 词： | 谷胱甘肽硫转移酶，基因调控，氧化应激，活性氧 |
| 收稿时间： | 1996/7/15 0:00:00 |
| 修稿时间： | 1996/10/27 0:00:00 |
Regulation of Glutathione S-Transferase Gene Expression |
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| PANG Zhanjun,CHEN Yuan and ZHOU Mei.Regulation of Glutathione S-Transferase Gene Expression[J].Progress In Biochemistry and Biophysics,1997,24(5):401-405. |
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| Authors: | PANG Zhanjun CHEN Yuan and ZHOU Mei |
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| Institution: | Laboratory of Free Radical Medicine, The First Military Medical University, Guangzhou 510515, China;Laboratory of Free Radical Medicine, The First Military Medical University, Guangzhou 510515, China;Laboratory of Free Radical Medicine, The First Military Medical University, Guangzhou 510515, China |
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| Abstract: | The proteins expressed by the glutathione S-transferase(GST) supergene family which catalyze the conjugation of endogenous or exogenous electrophiles with glutathione(GSH) are a family of detoxicating proteins,the gene expression of which is regulated by many sorts of compounds through different mechanisms. A brief review for the gene structure and regulation mechanisms associated with the expression of GSTs,and the action of oxidative stress in the regulation of GST gene expression was made. |
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| Keywords: | glutathione S-transferase(GST) gene expression regulation oxidative stress reactive oxygen species |
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