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脂质过氧化引起的DNA损伤研究进展
引用本文:刘晓麒,曹恩华.脂质过氧化引起的DNA损伤研究进展[J].生物化学与生物物理进展,1994,21(3):218-222.
作者姓名:刘晓麒  曹恩华
作者单位:中国科学院生物物理研究所;中国科学院生物物理研究所
摘    要:脂质过氧化可以引起各种碱基损伤、DNA链断裂和各种荧光产物生成,并对DNA分子鸟嘌呤碱基具有选择性损伤.过渡金属离子可以明显加深脂质过氧化对DNA的损伤程度.多种抗氧化剂、活性氧自由基清除剂对脂质过氧化引起的DNA损伤有一定程度的保护作用.具有致突、致癌作用的8-羟基鸟嘌呤已经观察到.脂质过氧化的致突变、致癌变作用机制引起了人们的极大兴趣.

关 键 词:脂质过氧化    DNA损伤    8-羟基鸟嘌呤    荧光产物    脂质    DNA
收稿时间:1993/1/29 0:00:00
修稿时间:5/6/1993 12:00:00 AM

DNA Damage Induced by Lipid Peroxidation
Liu Xiaoqi and Cao Enhua.DNA Damage Induced by Lipid Peroxidation[J].Progress In Biochemistry and Biophysics,1994,21(3):218-222.
Authors:Liu Xiaoqi and Cao Enhua
Institution:Institute of Biophysics, Academia Sinica;Institute of Biophysics, Academia Sinica
Abstract:Lipid peroxidation may lead to base modification,DNA strand breaks and formation of various fluorescent products in model systems,bacteria and eucaryotic cells.and the selective destruction of the base guanine in DNA.The transient metal ions can intensify the DNA damage obviously.Antioxidants and free radical scavagers have the protective effect of varying degrees for DNA damage induced by lipid peroxidation.8-Hydroxyguanine,which is strongly implicated in mutagenesis and carcino-genesis. has been observed.The molecular mechanism of mutagenesis and carcinogenesis induced by lipid peroxidation aroused great concerns in the field of free radical biology.
Keywords:lipid peroxidation  DNA damage  8-hydroxyguanine  fluorescence products  lipid  DNA
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