| 转铁蛋白受体2及其功能与相关疾病 |
| |
| 引用本文： | 常彦忠,段相林,钱忠明.转铁蛋白受体2及其功能与相关疾病[J].生物化学与生物物理进展,2003,30(4):533-536. |
| |
| 作者姓名： | 常彦忠 段相林 钱忠明 |
| |
| 作者单位： | 1. 香港理工大学应用生物及化学科技学系铁代谢实验室,九龙,香港
2. 香港理工大学应用生物及化学科技学系铁代谢实验室,九龙,香港;河北师范大学神经生物和神经药理学研究所,石家庄,050016 |
| |
| 基金项目： | 钱忠明博士实验室的研究得到香港政府RGC (PolyU5270/01/M/B-Q445)和香港理工大学研究基金（G-T616, A-PC98, A-PC23和GV-881)支持. |
| |
| 摘 要： | 转铁蛋白受体2(transferrin receptor 2, TfR2) 是最近发现的一种重要铁代谢蛋白.研究显示它不仅是一种介导肝脏细胞铁摄取的主要蛋白，而且在调节小肠铁吸收方面起着极其关键的作用，是控制肝脏铁调素合成和释放的关键成分.已经证实，TfR2基因突变是遗传性血色素沉着病的重要原因之一.
|
| 关 键 词： | 铁代谢，转铁蛋白受体2，铁吸收，遗传性血色素沉着病 |
| 收稿时间： | 2002/12/23 0:00:00 |
| 修稿时间： | 2002年12月23 |
Transferrin Receptor 2: Function and Relevant Disorders |
| |
| CHANG Yan-Zhong,DUAN Xiang-Lin and QIAN Zhong-Ming.Transferrin Receptor 2: Function and Relevant Disorders[J].Progress In Biochemistry and Biophysics,2003,30(4):533-536. |
| |
| Authors: | CHANG Yan-Zhong DUAN Xiang-Lin and QIAN Zhong-Ming |
| |
| Institution: | Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China;Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China; Institute of Neurobiology and Neuropharmacology, Hebei Normal University, Shijiazhuang 050016, China;Laboratory of Iron Metabolism, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China; Institute of Neurobiology and Neuropharmacology, Hebei Normal University, Shijiazhuang 050016, China |
| |
| Abstract: | Transferrin receptor 2 (TfR2) is a newly discovered iron metabolism protein. New findings indicate that in addition to the ability of TfR2 to mediate iron uptake by the liver cells, TfR2 is important in regulation of iron absorption in the small intestine via controlling synthesis and release of hepcidin. The studies have also demonstrated that mutation in the human transferrin receptor 2 gene is one of the causes for hereditory hemochormatosis. |
| |
| Keywords: | iron metabolism transferrin receptor 2 iron absorption hereditory hemochormatosis(G51) |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
|
