| 多光子显微成像技术在脑部疾病研究中的应用 |
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| 引用本文： | 黄燕霞,周非凡,周婷,许皓,林丹樱,屈军乐.多光子显微成像技术在脑部疾病研究中的应用[J].生物化学与生物物理进展,2019,46(10):952-965. |
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| 作者姓名： | 黄燕霞 周非凡 周婷 许皓 林丹樱 屈军乐 |
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| 作者单位： | 深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060,深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060,深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060,深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060,深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060,深圳大学物理与光电工程学院,光电子器件与系统（教育部/广东省）重点实验室,深圳 518060 |
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| 基金项目： | 国家自然科学基金61525503616201060166183500981727804;广东省高等学校科技创新（重点）项目2015KGJHZ002/2016KCXTD007;广东省自然科学基金2014A030312008;深圳市基础研究项目JCYJ20150930104948169JCYJ20160328144746940;JCYJ20170412105003520)资助.国家自然科学基金(61525503,61620106016,61835009,81727804),广东省高等学校科技创新（重点）项目（2015KGJHZ002/2016KCXTD007）,广东省自然科学基金(2014A030312008) 和深圳市基础研究项目 (JCYJ20150930104948169,JCYJ20160328144746940,JCYJ20170412105003520)资助. |
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| 摘 要： | 由于多光子显微技术具有高时空分辨率、低损伤性、可对活体长时间成像等特点,近年来已被广泛应用于生物医学等领域,并且在多种疾病诊断中展现出巨大的应用潜力.尤其是在脑部疾病的研究中,利用多光子成像技术可实现对复杂神经网络的研究,包括对脑部神经细胞、血管、肿瘤等进行实时成像并研究各自之间的相互作用,能进一步揭示脑疾病的发病机制并指导检测治疗方法的开发.本文简要介绍了多光子成像技术的基本原理及特点,总结了其在阿尔茨海默病、脑中风、脑肿瘤等多种脑部疾病中的应用,详细阐述了近年来利用多光子成像技术在脑部疾病研究中所获得的成果,并对多光子成像技术的发展前景进行了展望,预期其在脑部疾病的研究中将发挥更大的作用.
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| 关 键 词： | 多光子显微成像 脑部疾病 生物光学成像 |
| 收稿时间： | 2019/5/4 0:00:00 |
| 修稿时间： | 2019/7/1 0:00:00 |
Application of Multiphoton Microscopic Imaging in The Research on Brain Disease |
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| HUANG Yan-Xi,ZHOU Fei-Fan,ZHOU Ting,XU Hao,LIN Dan-Ying and QU Jun-Le.Application of Multiphoton Microscopic Imaging in The Research on Brain Disease[J].Progress In Biochemistry and Biophysics,2019,46(10):952-965. |
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| Authors: | HUANG Yan-Xi ZHOU Fei-Fan ZHOU Ting XU Hao LIN Dan-Ying and QU Jun-Le |
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| Institution: | Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China |
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| Abstract: | Multiphoton microscopy is an important biomedical imaging modality with great potential in the diagnosis of various diseases, due to high resolution, low damage, and long-term imaging of living organisms. Especially for the research on brain diseases, multiphoton microscopy can be used to observe neuron,blood vessels,tumors, and their interactions,which can further reveal the pathogenesis of brain diseases and direct the developement of diagnosis and treatment methods. This review introduces the basic principles and characteristics of multiphoton microscopy, and its applications in the study of various brain diseases, such as Alzheimer"s disease,stroke and tumor. We highlight recent achievements in brain diseases using multiphoton microscopy and give an outlook on the development of multiphoton microscopy that isexpected to play a greater role in the study of brain diseases. |
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| Keywords: | multiphoton microscopic imaging brain disease bio-optical imaging |
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