| N6-甲基腺苷修饰（m6A）在乳腺癌中的研究进展 |
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| 引用本文： | 方润平,许飞飞,赵路萍,于露,蔡晓丽,杨哲,张伟英,叶丽虹,史慧.N6-甲基腺苷修饰（m6A）在乳腺癌中的研究进展[J].生物化学与生物物理进展,2021,48(5):550-559. |
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| 作者姓名： | 方润平 许飞飞 赵路萍 于露 蔡晓丽 杨哲 张伟英 叶丽虹 史慧 |
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| 作者单位： | 2）南开大学生物化学与分子生物学实验室，天津 300071,2）南开大学生物化学与分子生物学实验室，天津 300071,1）济宁医学院免疫与分子研究所，济宁 272067,1）济宁医学院免疫与分子研究所，济宁 272067,2）南开大学生物化学与分子生物学实验室，天津 300071,3）辽宁大学生命科学学院，沈阳 110036,2）南开大学生物化学与分子生物学实验室，天津 300071,2）南开大学生物化学与分子生物学实验室，天津 300071,1）济宁医学院免疫与分子研究所，济宁 272067 |
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| 基金项目： | This work was supported by grants from The National Natural Science Foundation of China(81802856, 31800688), 请作者补充英文基金 |
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| 摘 要： | 乳腺癌是女性最常见的癌症之一,也是导致女性癌症死亡的最主要原因.尽管早期乳腺癌的治疗已经取得了极大进展,但晚期伴转移乳腺癌治疗效果较差,具有高复发率和高死亡率.因此,鉴定新的用于诊断和预测乳腺癌转移的分子标记、开发新的治疗策略成为迫切需要.近年来,mRNA的异常N~6-甲基腺苷修饰(N~6-methyladenosine,m~6A)对癌基因功能和表达水平的表观遗传学调控逐渐成为恶性乳腺癌研究的焦点.本文分析和总结了m~6A甲基化修饰及其调节蛋白参与调控乳腺癌发生发展的最新研究进展,以期为乳腺癌中m~6A甲基化修饰研究提供新的思路和参考,进一步为乳腺癌的诊断、治疗、预后及监测提供新的有效策略.
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| 关 键 词： | m6A m6A调节蛋白 RNA修饰 表观遗传 乳腺癌 |
| 收稿时间： | 2020/9/30 0:00:00 |
| 修稿时间： | 2020/10/28 0:00:00 |
The Roles of m6A Modification in Breast Cancer |
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| FANG Run-Ping,XU Fei-Fei,ZHAO Lu-Ping,YU Lu,CAI Xiao-Li,YANG Zhe,ZHANG Wei-Ying,YE Li-Hong and SHI Hui.The Roles of m6A Modification in Breast Cancer[J].Progress In Biochemistry and Biophysics,2021,48(5):550-559. |
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| Authors: | FANG Run-Ping XU Fei-Fei ZHAO Lu-Ping YU Lu CAI Xiao-Li YANG Zhe ZHANG Wei-Ying YE Li-Hong and SHI Hui |
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| Institution: | 2)State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China,2)State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China,1)Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China,1)Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China,2)State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China,3)School of Life Sciences, Liaoning University, Shenyang 110036, China,2)State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China,2)State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071, China,1)Institute of Immunology and Molecular Medicine, Jining Medical University, Jining 272067, China |
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| Abstract: | Breast cancer is the most common cancer and the leading cause of cancer death in women worldwide. Although huge progress has been made in managing early-stage breast cancer, no effective strategy can prevent or treat breast cancer metastasis which has high recurrence rate and high mortality rate. Thus, identification of new molecular markers for the diagnosis and prognostic prediction of metastatic breast cancer and development of innovative therapeutic measures are urgently needed. Recently, epigenetic regulation of the expression and function of oncogenes by aberrant N6-methyladenosine (m6A) modification of mRNA in aggressive breast cancer is investigated widely. In this review, we retrieve and analyze the most recent studies on m6A modification, and summarize the expression and the function of m6A regulatory proteins, including the writers, erasers and readers, in the tumorigenesis and progression of breast cancer, and point out the defects in the recent field of m6A-related researches, so as to provide scientific basis for diagnosis, therapies and prognosis in breast cancer. |
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| Keywords: | N6-methyladenosine RNA-modifying proteins RNA modifications epigenetic modification breast cancer |
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