| 凋亡小体与炎症小体：Caspase蛋白酶的激活平台 |
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| 引用本文： | 柴继杰,施一公.凋亡小体与炎症小体：Caspase蛋白酶的激活平台[J].生物化学与生物物理进展,2014,41(10):1056-1062. |
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| 作者姓名： | 柴继杰 施一公 |
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| 作者单位： | 清华大学生命科学学院，清华北大联合中心，北京 100084,清华大学生命科学学院，清华北大联合中心，北京 100084 |
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| 摘 要： | 多细胞生物的细胞凋亡(apoptosis)和炎症反应(inflammation)分别在内稳态维持和对抗外源微生物入侵的过程中具有重要作用.凋亡小体和炎症小体则是调节这两种生物学过程的关键复合物.凋亡小体和炎症小体的功能都是作为caspase的激活平台,但是前者激活caspase-9,而后者则是激活炎症性caspase-1.本文综述近年来关于这两类复合体激活机制的研究进展.
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| 关 键 词： | 细胞凋亡 炎症反应 caspase |
| 收稿时间： | 2014/10/8 0:00:00 |
| 修稿时间： | 2014/10/8 0:00:00 |
Apoptosome and Inflammasome: a Caspase-activating Platform |
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| CHAI Ji-Jie and SHI Yi-Gong.Apoptosome and Inflammasome: a Caspase-activating Platform[J].Progress In Biochemistry and Biophysics,2014,41(10):1056-1062. |
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| Authors: | CHAI Ji-Jie and SHI Yi-Gong |
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| Institution: | School of Life Sciences, Tsinghua University, Beijing 100084, China and School of Life Sciences, Tsinghua University, Beijing 100084, China |
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| Abstract: | In multicellular organisms, the ligand-induced multiprotein complexes apoptosomes and inflammasomes are major players mediating apoptosis and inflammation, respectively. Both types of complexes function as a caspase-activating platform, but apoptosomes are specific for the apoptotic caspases such as caspase-9, whereas inflammasomes for inflammatory caspases like caspase-1. Here we summarize recent progresses on the molecular mechanisms underlying assembly and activation of the two types of protein complexes. |
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| Keywords: | apoptosome inflammasome caspase |
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