综述——基于纳米材料的生物检测与医学诊断技术：功能化量子点在肿瘤活体成像中的应用

量子点表面经生物分子或药物分子修饰而具有生物功能．功能化量子点具有独特的光学性质和生物相容性，在生物医学光学诊断和治疗领域具有广泛的应用．本文简要介绍了功能化量子点制备及修饰方法，综合评述了量子点在肿瘤活体诊断和治疗中的应用，包括活体淋巴结成像、血管动态成像、肿瘤成像和抗肿瘤药物示踪等，讨论了功能化量子点在肿瘤活体诊断和治疗中的应用前景以及面临的挑战．

Review: Applications of Functionalized Quantum Dots in Tumor in vivo Imaging

The quantum dots (QDs) will have biological function by surface modification with biomolecules or drug molecules. The functionalized QDs have been widely applied in biomedical optical diagnosis and therapy for their unique optical propriety and biocompatibility. This paper introduced the synthesis and modification methods of functionalized QDs, and summarized their applications for tumor in vivo diagnosis and therapy, including in vivo lymph node imaging, blood vessel dynamic imaging, tumor imaging and anti-tumor drug tracking, et al. Finally, we also discussed the perspective and the challenge of the functionalized QDs utilization for the tumor in vivo diagnosis and therapy.