| 假单胞菌生物被膜核心胞外多糖生物合成系统研究进展 |
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| 引用本文： | 刘佳文,吴倩,张昭寰,童金蓉,黄振华,刘静,潘迎捷,赵勇.假单胞菌生物被膜核心胞外多糖生物合成系统研究进展[J].生物化学与生物物理进展,2022,49(2):273-283. |
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| 作者姓名： | 刘佳文 吴倩 张昭寰 童金蓉 黄振华 刘静 潘迎捷 赵勇 |
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| 作者单位： | 1）上海海洋大学食品学院，上海 201306,1）上海海洋大学食品学院，上海 201306,1）上海海洋大学食品学院，上海 201306;2）上海海洋大学水产与生命学院，上海 201306,1）上海海洋大学食品学院，上海 201306,1）上海海洋大学食品学院，上海 201306,1）上海海洋大学食品学院，上海 201306,1）上海海洋大学食品学院，上海 201306;3）农业农村部水产品贮藏保鲜质量安全风险评估实验室（上海），上海 201306;4）上海水产品加工及贮藏工程技术研究中心，上海 201306,1）上海海洋大学食品学院，上海 201306;3）农业农村部水产品贮藏保鲜质量安全风险评估实验室（上海），上海 201306;4）上海水产品加工及贮藏工程技术研究中心，上海 201306 |
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| 基金项目： | 国家博士后创新人才支持计划（BX20190194），国家自然科学基 金（32001800），上海市“超级博士后”激励计划（2019348） 和中 国博士后科学基金（2019M661469） 资助项目。 |
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| 摘 要： | 胞外多糖是假单胞菌生物被膜的重要组成部分,能增强菌体对外界环境、抗菌剂和宿主防御的耐受性。假单胞菌能产生3种与生物被膜形成密切相关的核心胞外多糖:褐藻胶、Psl和Pel,它们在细菌细胞中的合成和转运分别依赖对应的褐藻胶、Psl和Pel生物合成系统。因此,本综述系统全面地总结了假单胞菌3种胞外多糖生物合成系统结构生物学的研究进展,重点围绕已知结构的蛋白质进行具体的结构和功能阐述。在此基础之上,对未来研究方向提出新的思路和见解,可为假单胞菌生物被膜形成机制及控制策略奠定扎实的理论基础。
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| 关 键 词： | 假单胞菌 生物被膜 核心胞外多糖 褐藻胶生物合成系统 Psl生物合成系统 Pel生物合成系统 |
| 收稿时间： | 2021/3/1 0:00:00 |
| 修稿时间： | 2021/5/31 0:00:00 |
Research Progress on Pseudomonas Biofilm Formation-related Key Extracellular Polysaccharide Biosynthetic Systems |
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| LIU Jia-Wen,WU Qian,ZHANG Zhao-Huan,TONG Jin-Rong,HUANG Zhen-Hu,LIU Jing,PAN Ying-Jie and ZHAO Yong.Research Progress on Pseudomonas Biofilm Formation-related Key Extracellular Polysaccharide Biosynthetic Systems[J].Progress In Biochemistry and Biophysics,2022,49(2):273-283. |
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| Authors: | LIU Jia-Wen WU Qian ZHANG Zhao-Huan TONG Jin-Rong HUANG Zhen-Hu LIU Jing PAN Ying-Jie and ZHAO Yong |
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| Institution: | 1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;2)College of Fisheries and Life Sciences, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;3)Laboratory of Quality & Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China;4)Shanghai Engineering Research Centre of Aquatic-Product Processing & Preservation, Shanghai 201306, China,1)College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;3)Laboratory of Quality & Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China;4)Shanghai Engineering Research Centre of Aquatic-Product Processing & Preservation, Shanghai 201306, China |
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| Abstract: | Extracellular polysaccharides serve as the major structural components of Pseudomonas biofilm matrix, which can enhance the tolerance of bacteria for environment, antimicrobials and host defense. Pseudomonas mainly produce three key extracellular polysaccharides implicated in biofilm formation: alginate, Psl and Pel, and their synthesis and transport depend on the corresponding alginate, Psl and Pel biosynthetic systems. Therefore, this review comprehensively summarizes the progress on structural biology of Pseudomonas biofilm formation-related three exopolysaccharide biosynthetic systems, and describes the known structures and functions of proteins in these three systems. On this basis, new insights are put forward for future research directions, which can lay a solid theoretical foundation for formation mechanism and control strategies of Pseudomonas biofilm. |
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| Keywords: | Pseudomonas biofilm key extracellular polysaccharide alginate biosynthetic system Psl biosynthetic system Pel biosynthetic system |
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