| 研究报告：抗肿瘤药物长循环高分子脂质体的研究 |
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| 引用本文： | 王生,王化泉,王汉杰,苏文雅,王亮亮,彭瑶,韩磊,常津.研究报告：抗肿瘤药物长循环高分子脂质体的研究[J].生物化学与生物物理进展,2013,40(10):1063-1069. |
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| 作者姓名： | 王生 王化泉 王汉杰 苏文雅 王亮亮 彭瑶 韩磊 常津 |
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| 作者单位： | 天津大学材料学院纳米生物技术研究所，天津 300072,天津医科大学总医院，天津 300052,天津大学材料学院纳米生物技术研究所，天津 300072,天津大学材料学院纳米生物技术研究所，天津 300072,天津大学材料学院纳米生物技术研究所，天津 300072,天津大学材料学院纳米生物技术研究所，天津 300072,天津医科大学总医院，天津 300052,天津大学材料学院纳米生物技术研究所，天津 300072 |
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| 基金项目： | 国家高技术研究发展计划(863)(2012AA022603), 高等学校博士学科点专项科研基金(20120032110027)和国家自然科学基金(51373117)资助项目, 天津市自然科学基金重点项目(13JCZDJC33200) |
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| 摘 要： | 脂质体作为一种药物基因载体已得到广泛应用，然而其仍然具有物理化学稳定性差、易发生团聚、难以多功能化等缺点．通过使用合成的双亲性高分子共轭亚油酸修饰聚赖氨酸(PC)代替小分子磷脂制备的高分子脂质体(PLs)，不仅保留了脂质体的优势，并且克服了上述缺点；通过对高分子进行聚乙二醇(PEG)修饰，可使制备的高分子脂质体具有长循环性．结果表明，高分子脂质体粒径为纳米级，具有药物缓释性能、较低的细胞毒性及较高的细胞内吞效率．
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| 关 键 词： | 抗肿瘤，药物载体，高分子脂质体，聚赖氨酸，共轭亚油酸 |
| 收稿时间： | 2013/4/25 0:00:00 |
| 修稿时间： | 8/5/2013 12:00:00 AM |
Review: The Research of Anti-Tumor Drugs Long Circulating Polymeric Liposomes |
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| WANG Sheng,WANG Hua-Quan,WANG Han-Jie,SU Wen-Y,WANG Liang-Liang,PENG Yao,HAN Lei and CHANG Jin.Review: The Research of Anti-Tumor Drugs Long Circulating Polymeric Liposomes[J].Progress In Biochemistry and Biophysics,2013,40(10):1063-1069. |
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| Authors: | WANG Sheng WANG Hua-Quan WANG Han-Jie SU Wen-Y WANG Liang-Liang PENG Yao HAN Lei and CHANG Jin |
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| Institution: | Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Tianjin Medical University General Hospital, Tianjin 300052, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China,Tianjin Medical University General Hospital, Tianjin 300052, China and Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, China |
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| Abstract: | Recently, liposomes have gained attention as a promising tool for drug and gene delivery. However, their applications have been constrained by their poor stability, aggregation and difficult to functional. Using amphiphilc conjugated linoleic acid modified polylysine (PC) and cholesterol, we developed a novel polymeric liposomes (PLs). These PLs retained the advantages of conventional liposomes (CLs), and overcome the above disadvantages of CLs. In addition, PEG chains coated on the PLs surface can prolong their circulation time in the blood. These results suggest that the PLs were nano-sized, achieved a sustained release of drugs, showed limited cytotoxicity and increased uptake in LN229 glioblastoma cells. |
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| Keywords: | anti-tumor drug delivery system polymeric liposomes polylysine conjugated linoleic acid |
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