| 丝状真菌胞外蛋白高效分泌机制的研究进展 |
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| 引用本文： | 周娜娜,王禄山,公维丽,赵越,张怀强.丝状真菌胞外蛋白高效分泌机制的研究进展[J].生物化学与生物物理进展,2016,43(1):44-54. |
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| 作者姓名： | 周娜娜 王禄山 公维丽 赵越 张怀强 |
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| 作者单位： | 山东大学微生物技术国家重点实验室，济南 250100,山东大学微生物技术国家重点实验室，济南 250100,山东大学微生物技术国家重点实验室，济南 250100,山东大学微生物技术国家重点实验室，济南 250100,山东大学微生物技术国家重点实验室，济南 250100 |
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| 基金项目： | 国家自然科学基金(31370111，31170071)和山东省自然科学基金(ZR2013CM038)资助项目 |
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| 摘 要： | 丝状真菌由于其胞外蛋白分泌的高效性,成为生产酶制剂的高效细胞工厂.近年来针对真核生物胞外蛋白分泌途径的研究发现,丝状真菌蛋白的分泌途径相比其他真核生物具有高效分泌的特性.为了研究丝状真菌高效分泌的机制,本文总结了近年来丝状真菌分泌途径的最新研究进展,并且选取了分泌途径中关键环节的数种蛋白进行分析,通过与其他真核生物相关蛋白进行结构与序列比对,推测了丝状真菌胞外蛋白高效分泌的可能机制.
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| 关 键 词： | 丝状真菌，顶端分泌，高效分泌机制，序列比对，结构比对 |
| 收稿时间： | 2015/7/28 0:00:00 |
| 修稿时间： | 2015/12/6 0:00:00 |
Research Progress on The Efficient Secretion Mechanism of Extracellular Proteins in Filamentous Fungi |
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| ZHOU Na-N,WANG Lu-Shan,GONG Wei-Li,ZHAO Yue and ZHANG Huai-Qiang.Research Progress on The Efficient Secretion Mechanism of Extracellular Proteins in Filamentous Fungi[J].Progress In Biochemistry and Biophysics,2016,43(1):44-54. |
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| Authors: | ZHOU Na-N WANG Lu-Shan GONG Wei-Li ZHAO Yue and ZHANG Huai-Qiang |
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| Institution: | The State Key Laboratory of Microbiol Technology, Shandong University, Jinan 250100, China,The State Key Laboratory of Microbiol Technology, Shandong University, Jinan 250100, China,The State Key Laboratory of Microbiol Technology, Shandong University, Jinan 250100, China,The State Key Laboratory of Microbiol Technology, Shandong University, Jinan 250100, China and The State Key Laboratory of Microbiol Technology, Shandong University, Jinan 250100, China |
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| Abstract: | Filamentous fungi are efficient cell factories in producing industrial enzyme products as the efficiency in extracellular proteins secretion. Most researches on extracellular proteins secretion in new century found that the protein secretion pathway of filamentous fungi had an efficient secretion mechanism compared with other eukaryotes'. In order to explore the efficient mechanism, this paper summarized the latest research progresses of secretory pathway in filamentous fungi. The key proteins in the secretory pathway were selected to perform sequence alignment and structure alignment. And the possible efficient secretion mechanism was put forward. |
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| Keywords: | filamentous fungi apocrine secretion efficient secretion mechanism sequence alignment structure alignment |
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