| c-Myc部分通过调控Nbs1减弱阿霉素降低U2OS细胞集落形成的能力 |
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| 引用本文： | 施寒清,黄慧,张玺涛,张建超,雒秀坦,彭秀娥,黄百渠,陆军.c-Myc部分通过调控Nbs1减弱阿霉素降低U2OS细胞集落形成的能力[J].生物化学与生物物理进展,2010,37(8):855-863. |
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| 作者姓名： | 施寒清 黄慧 张玺涛 张建超 雒秀坦 彭秀娥 黄百渠 陆军 |
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| 作者单位： | 东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024；大庆石油学院石油工程学院，大庆 163318;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024;东北师范大学遗传与细胞研究所教育部表观遗传重点实验室，长春 130024 |
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| 基金项目： | 国家重点基础研究发展计划(973)(2005CB522404, 2006CB910506), 长江学者和创新团队发展计划(IRT0519)和国家自然科学基金(30771232, 30671184)资助项目 |
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| 摘 要： | c-Myc是一种泛在性的转录因子，它调控着许多涉及细胞增殖、分化、凋亡等生命活动的基因．实验结果表明在骨肉瘤细胞U2OS中过表达c-Myc和Nbs1都能减弱阿霉素降低集落形成的能力．进一步的实验证实c-Myc的这种作用与Nbs1有关，Nbs1是c-Myc的靶基因．染色质免疫沉淀实验显示，c-Myc招募组蛋白乙酰化酶p300复合物到Nbs1启动子区，引起了组蛋白H4的乙酰化，定位在Nbs1启动子区的相邻的两个E-box对c-Myc的结合是必要的．上述结果说明c-Myc减弱阿霉素的作用部分是通过调控Nbs1来实现的．这也提示了c-Myc在阿霉素诱导的DNA损伤修复中起作用．
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| 关 键 词： | c-Myc，Nbs1， 阿霉素，集落形成， p300 |
| 收稿时间： | 2010/1/25 0:00:00 |
| 修稿时间： | 2010/3/15 0:00:00 |
c-Myc Attenuates The Ability of Doxorubicin to Reduce The Colony Formation Partially Through Regulating Nbs1 in U2OS Cells |
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| SHI Han-Qing,HUANG Hui,ZHANG Xi-Tao,ZHANG Jian-Chao,LUO Xiu-Tan,PENG Xiu-E,HUANG Bai-Qu and LU Jun.c-Myc Attenuates The Ability of Doxorubicin to Reduce The Colony Formation Partially Through Regulating Nbs1 in U2OS Cells[J].Progress In Biochemistry and Biophysics,2010,37(8):855-863. |
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| Authors: | SHI Han-Qing HUANG Hui ZHANG Xi-Tao ZHANG Jian-Chao LUO Xiu-Tan PENG Xiu-E HUANG Bai-Qu and LU Jun |
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| Institution: | Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Institute of Petroleum Engineering, Daqing Petroleum Institute, Daqing 163318, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China;Key Laboratory of Molecular Epigenetics of (Ministry of Education) MOE, Institute of Genetics and Cytology,Northeast Normal University, Changchun 130024, China |
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| Abstract: | |
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| Keywords: | c-Myc Nbs1 doxorubicin colony formation p300 |
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