| 夜间光照对褪黑激素抑制的量化计算 |
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| 引用本文： | 孟扬,贺珍妮,尹健,张宇,张天浩.夜间光照对褪黑激素抑制的量化计算[J].生物化学与生物物理进展,2010,37(6):686-689. |
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| 作者姓名： | 孟扬 贺珍妮 尹健 张宇 张天浩 |
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| 作者单位： | 天津医科大学附属肿瘤医院乳腺科，乳腺癌防治教育部重点实验室，天津市肿瘤防治重点实验室，天津 300060；南开大学物理科学学院光子学中心，生物活性材料教育部重点实验室，弱光非线性光子学教育部实验室，天津市信息光子材料与技术重点实验室，天津 300071;天津大学仁爱学院物理实验中心，天津301636;天津医科大学附属肿瘤医院乳腺科，乳腺癌防治教育部重点实验室，天津市肿瘤防治重点实验室，天津 300060;南开大学物理科学学院光子学中心，生物活性材料教育部重点实验室，弱光非线性光子学教育部实验室，天津市信息光子材料与技术重点实验室，天津 300071;南开大学物理科学学院光子学中心，生物活性材料教育部重点实验室，弱光非线性光子学教育部实验室，天津市信息光子材料与技术重点实验室，天津 300071 |
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| 基金项目： | 长江学者和创新团队发展计划资助项目 |
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| 摘 要： | 作为人体的重要激素之一，褪黑激素具备重要的生理功能．不适当的夜间光照会造成人体生物钟节律的异常，进而导致褪黑激素内分泌的抑制．夜间光照引起的褪黑激素抑制与光的波长和色温关系密切．此前尚仍缺乏一个夜间光照对褪黑激素抑制效果的量化计算方案．提出了一种夜间光照对褪黑激素抑制的量化算法，拟合了人体血液褪黑激素抑制率的相对光谱灵敏度归一化曲线，建立了夜间光照与褪黑激素抑制量化计算的算法模型．研究结果为室内安全光照环境的设计提供了理论依据和计算方法，并可在光污染的控制、夜间安全环境照明标准的制定等方面得到应用．
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| 关 键 词： | 夜间光照，褪黑激素抑制，光谱灵敏度曲线，生物钟节律，算法 |
| 收稿时间： | 4/6/2010 12:00:00 AM |
| 修稿时间： | 2010/5/10 0:00:00 |
Quantitative Algorithm for Melatonin Suppression by Light at Night |
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| MENG Yang,HE Zhen-Ni,YIN Jian,ZHANG Yu and ZHANG Tian-Hao.Quantitative Algorithm for Melatonin Suppression by Light at Night[J].Progress In Biochemistry and Biophysics,2010,37(6):686-689. |
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| Authors: | MENG Yang HE Zhen-Ni YIN Jian ZHANG Yu and ZHANG Tian-Hao |
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| Institution: | Department of Breast, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy of The Ministry of Education, and Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China;Photonics Research Center, School of Physics, the MOE Key Laboratory of Bioactive Materials, the MOE Key Laboratory of Weak-Light Nonlinear Photonics, and Tianjin Key Laboratory of Photonics Materials and Technology for Information Science, Nankai University, Tianjin 300071, China;Physics Experiment Center, Renai Collage of Tianjin University, Tianjin 301636, China;Department of Breast, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy of The Ministry of Education, and Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China;Photonics Research Center, School of Physics, the MOE Key Laboratory of Bioactive Materials, the MOE Key Laboratory of Weak-Light Nonlinear Photonics, and Tianjin Key Laboratory of Photonics Materials and Technology for Information Science, Nankai University, Tianjin 300071, China;Photonics Research Center, School of Physics, the MOE Key Laboratory of Bioactive Materials, the MOE Key Laboratory of Weak-Light Nonlinear Photonics, and Tianjin Key Laboratory of Photonics Materials and Technology for Information Science, Nankai University, Tianjin 300071, China |
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| Abstract: | As an important hormone, melatonin has a wide range of functions in human body. Inappropriate light at night (LAN) will cause abnormal human circadian rhythm and then lead to melatonin secretion suppression. Melatonin suppression depends on correlated color temperature (CCT) and wavelengths of LAN. So far there was no quantitative algorithm for melatonin suppression by LAN. A relative spectral sensitivity curve of human plasma melatonin suppression was fitted and an algorithm was presented for predicting melatonin suppression by LAN. Theoretical basis and a method were provided for instructing safety strategy of architectural light at night. Also, the results could be applied in controlling light pollution, formulating the standard of safety nocturnal environment illumination and some other fields. |
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| Keywords: | light at night melatonin suppression spectra sensitivity curve algorithm |
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