| 膜转运蛋白ABCA1与2型糖尿病 |
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| 引用本文： | 刘振,贺贞,马卫列,张志珍.膜转运蛋白ABCA1与2型糖尿病[J].生物化学与生物物理进展,2011,38(9):797-803. |
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| 作者姓名： | 刘振 贺贞 马卫列 张志珍 |
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| 作者单位： | 广东医学院生物化学与分子生物学教研室，东莞 523808;广东医学院生物化学与分子生物学教研室，东莞 523808;广东医学院生物化学与分子生物学教研室，东莞 523808;广东医学院生物化学与分子生物学教研室，东莞 523808；广东医学院衰老研究所，东莞 523808 |
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| 基金项目： | 东莞市高等院校科研机构科技计划项目(200910815263, 2008108102246) |
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| 摘 要： | 胰岛β细胞机能失调是2型糖尿病发病机理的关键所在,而细胞内胆固醇积聚是2型糖尿病β细胞机能失调的发生机制.胆固醇转运体———三磷酸腺苷结合盒转运子A1(ABCA1)缺乏,导致胰岛内胆固醇增加及胰岛素分泌受损,这表明胆固醇流出受损导致β细胞发生功能障碍.
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| 关 键 词： | ABCA1 糖尿病 胰岛β细胞 胆固醇 |
| 收稿时间： | 2010/10/18 0:00:00 |
| 修稿时间： | 2011/3/30 0:00:00 |
Membrane transport protein ABCA1 and Type 2 diabetes mellitus |
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| LIU Zhen,HE Zhen,MA Wei-Lie and ZHANG Zhi-Zhen.Membrane transport protein ABCA1 and Type 2 diabetes mellitus[J].Progress In Biochemistry and Biophysics,2011,38(9):797-803. |
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| Authors: | LIU Zhen HE Zhen MA Wei-Lie and ZHANG Zhi-Zhen |
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| Institution: | Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan 523808, China;Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan 523808, China;Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan 523808, China;Department of Biochemistry and Molecular Biology, Guangdong Medical College, Dongguan 523808, China;Institute of Aging, Guangdong Medical College, Dongguan 523808, China |
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| Abstract: | Beta cell dysfunction is a critical step in the pathogenesis of type 2 diabetes mellitus, while cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol efflux leads to beta cell dysfunction. |
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| Keywords: | ABCA1 diabetes mellitus beta cell cholesterol |
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