| 诱导型细胞的研究进展 |
| |
| 引用本文： | 王 龙,华进联.诱导型细胞的研究进展[J].生物化学与生物物理进展,2012,39(4):327-334. |
| |
| 作者姓名： | 王 龙 华进联 |
| |
| 作者单位： | 西北农林科技大学 |
| |
| 基金项目： | 国家自然科学基金，教育部重点科研项目，中国博士后科学基金特别资助项目，教育部新世纪优秀人才支持计划 |
| |
| 摘 要： | 胚胎干细胞(ES细胞)和诱导型多能干细胞(iPS细胞)的研究进展为生物学基础研究注入了新的活力，然而免疫排斥、致瘤性以及诱导效率低等缺陷制约其进一步快速发展和临床应用．最近，科学家借鉴iPS细胞诱导技术和传统的诱导体系，将终末分化细胞直接诱导为功能性细胞，如心肌细胞、神经细胞和肝脏细胞，称为诱导型细胞．这些研究进展极大地促进了细胞分化、重编程和表观遗传学的研究，也为人类再生医学的研究提供了新的途径．
|
| 关 键 词： | 胚胎干细胞，诱导型多能干细胞，诱导型细胞，功能细胞，转分化 |
| 收稿时间： | 2011/11/1 0:00:00 |
| 修稿时间： | 2012/2/27 0:00:00 |
Recent Progress in Induced Cells |
| |
| WANG Long and HUA Jin-Lian.Recent Progress in Induced Cells[J].Progress In Biochemistry and Biophysics,2012,39(4):327-334. |
| |
| Authors: | WANG Long and HUA Jin-Lian |
| |
| Institution: | **(College of Veterinary Medicine,Shaanxi Centre of Stem Cells Engineering & Technology,Key Laboratory for Animal Biotechnology of Agriculture Ministry,Northwest A & F University,Yangling 712100,China) |
| |
| Abstract: | The achievements of embryonic stem (ES) cells and induced pluripotent stem (iPS) cells provide new routes for biological research. However, the problems of immunological rejection, teratoma formation and low efficiency limit the further application. Recently, taking advantage of the systems for iPS cell derivation and traditional induction technologies, scientists induced terminally differentiated cells into functional cells such as cardiomyocytes, neurons and hepatocyte-like cells. These inspiring progresses boost the research on cell differentiation, reprogramming and epigenetics, providing new direction for regenerative medicine studies. |
| |
| Keywords: | embryonic stem cells induced pluripotent stem cells induced cells functional cells transdifferentiation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
