| 急性缺氧和急性低糖对脑片tau蛋白磷酸化的影响 |
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| 引用本文： | 刘蓉,王小川,黄尧,何志松,楮淑娟,汤芸,田青,王建枝.急性缺氧和急性低糖对脑片tau蛋白磷酸化的影响[J].生物化学与生物物理进展,2004,31(5):402-408. |
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| 作者姓名： | 刘蓉 王小川 黄尧 何志松 楮淑娟 汤芸 田青 王建枝 |
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| 作者单位： | 华中科技大学同济医学院病理生理学系,武汉 430030 |
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| 基金项目： | 国家自然科学基金，国家重点基础研究发展计划(973计划)，姜学谊基金 |
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| 摘 要： | 为探讨急性缺氧对tau蛋白磷酸化的影响,将Wistar大鼠脑片进行不同时间的缺氧培养后,对tau蛋白的磷酸化状态及相关磷酸酯酶的活性和表达进行检测.结果显示,急性缺氧使tau蛋白多个丝氨酸位点磷酸化水平下降,蛋白磷酸酯酶～2A(PP-2A)的活性升高,其催化亚单位表达上调,而蛋白磷酸酯酶-1(PP-1)的活性及催化亚单位表达均无明显改变.该研究结果表明:急性缺氧可能通过蛋白磷酸酯酶-2A的上调而使tau蛋白多个丝氨酸位点发生去磷酸化作用.
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| 关 键 词： | 缺氧 tau蛋白 磷酸化 磷酸酯酶-2A |
| 收稿时间： | 2003/9/29 0:00:00 |
| 修稿时间： | 2003/11/28 0:00:00 |
Effect of Acute Hypoxia on tau Phosphorylation in Rat Brain Slices |
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| LIU Rong,WANG Xiao-Chuan,HUANG Yao,HE Zhi-Song,CHU Shu-Juan,TANG Yun,TIAN Qing and WANG Jian-Zhi.Effect of Acute Hypoxia on tau Phosphorylation in Rat Brain Slices[J].Progress In Biochemistry and Biophysics,2004,31(5):402-408. |
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| Authors: | LIU Rong WANG Xiao-Chuan HUANG Yao HE Zhi-Song CHU Shu-Juan TANG Yun TIAN Qing and WANG Jian-Zhi |
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| Institution: | Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China;Department of Pathophysiology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | |
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| Keywords: | hypoxia tau phosphorylation protein phosphatase-2A |
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