| 羟自由基对培养细胞损伤作用的实验观察 |
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| 引用本文： | 汪德清,沈文梅,田亚平,董振南,刘国廉,孙仲怡,杨素霞,周淑珍.羟自由基对培养细胞损伤作用的实验观察[J].生物化学与生物物理进展,1995,22(3):278-281. |
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| 作者姓名： | 汪德清 沈文梅 田亚平 董振南 刘国廉 孙仲怡 杨素霞 周淑珍 |
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| 作者单位： | 解放军总医院生化科;解放军总医院生化科;解放军总医院生化科;解放军总医院生化科;军事医学科学院放射医学研究所;军事医学科学院放射医学研究所;军事医学科学院放射医学研究所;军事医学科学院放射医学研究所 |
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| 摘 要： | 将不同浓度的H2O2与V79细胞共同孵育24、48h后,结果显示SOD活性下降,LPO含量增加,细胞内GPT、GOT、LDH和CPK酶活性升高,其变化程度与培养时间和H2O2浓度成正比.
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| 关 键 词： | 羟自由基 V79细胞 SOD LPO |
| 收稿时间： | 5/4/1994 12:00:00 AM |
| 修稿时间： | 8/2/1994 12:00:00 AM |
Cell Damage in Chinese Hamster V79 Cells Treated With Hydrogen Peroxide |
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| Wang Deqing,Shen Wenmei,Tian Yaping,Dong Zhennan,Liu Guolian,Sun Zhongyi,Yang Suxia and Zhuo Shuzhen.Cell Damage in Chinese Hamster V79 Cells Treated With Hydrogen Peroxide[J].Progress In Biochemistry and Biophysics,1995,22(3):278-281. |
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| Authors: | Wang Deqing Shen Wenmei Tian Yaping Dong Zhennan Liu Guolian Sun Zhongyi Yang Suxia and Zhuo Shuzhen |
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| Institution: | Department of Biochemistry, General Hospital of PLA;Department of Biochemistry, General Hospital of PLA;Department of Biochemistry, General Hospital of PLA;Department of Biochemistry, General Hospital of PLA;Institute of Radiation Medicine, Academy of Military Medical Sciences;Institute of Radiation Medicine, Academy of Military Medical Sciences;Institute of Radiation Medicine, Academy of Military Medical Sciences;Institute of Radiation Medicine, Academy of Military Medical Sciences |
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| Abstract: | When Cmnese Hamster V79 cells were incubated with H2O2 of different concentration for 24h and 48h,different degree damages in cells have been found.The activity of SOD decreased and lipid peroxides contents increased in cultured cells.It is also shown that the activies of metabolites,such as GPT,GOT,LDH and CPK,are higher than those in control,is in direct proportion to the H2O2 concentration and the incubation time. |
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| Keywords: | hydroxyl radical V79 cells SOD LPO |
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