广谱抗病毒抑制剂研究进展

研制广谱抗病毒制剂是病毒学前瞻性方向,也是国际医药界倍受瞩目的热点之一.近年来,广谱抗病毒制剂相关研究获得长足进展,突破了抗病毒制剂单一宿主的瓶颈与限制,以及广谱类制剂活性相对较弱的原有思维,部分成果已面向临床应用.本文基于病毒侵染以及宿主细胞防御两个层面,全面综述新型广谱抗病毒抑制剂的研究进展与应用潜力,讨论现存的挑战,并展望了未来研究趋势.

Advances in Development of Broad-spectrum Antiviral Agents

The development of broad-spectrum antiviral agents has recently become a major thrust area in the field of virology, and received enormous attention in the pharmaceutical industry worldwide. Much progress has been made to substantially extend the limitations of current antiviral therapy drugs, which are mostly pathogen-specific. Breakthroughs were made in establishing fundamental understanding of the underlying biochemical mechanisms. Part of the research results have been implemented for practical applications. The present review addresses the state-of-the-art knowledge, prospective applications, and challenges for the development of broad-spectrum antiviral agents. Detailed models of agent targets to virus entry and infection, and host cell defense are given. Finally, future research needs and opportunities are discussed.