铁死亡：一种新的细胞死亡方式

死亡不仅是所有细胞的最终命运,而且它与细胞分裂、增殖一样,在整个机体的生长、发育中具有不可替代的作用.目前认为,除了坏死外,细胞死亡形式分为程序性细胞死亡(programmedcell death,PCD),包括凋亡(apoptosis)和自噬(autophagy),及非程序性细胞死亡(non-programmedcell death,NPCD),包括副凋亡(paraptosis)、细胞有丝分裂灾难(mitotic catastrophe)和胀亡(oncosis)

Ferroptosis: A New Mechanism of Cell Death

Ferroptosis is proposed to result from overwhelming iron-dependent oxidative injury, which is distinct from apoptosis, necrosis, and autophagy. This iron-dependent process is marked by increased levels of cytosolic and lipid reactive oxygen species (ROS) and abnormally small mitochondria with increased membrane density. Ferroptosis is similar to glutamate-induced excitotoxicity. Recently, many reports have revealed that ferroptosis is precisely regulated by some cellular signaling pathways, like apoptosis, including regulators of iron homeostasis, RAS pathway induction of oxidase gene expression, and cystine transport impacting glutathione synthesis. Ferroptosis contributes to the process of neurodegeneration and strategy to kill RAS-mutant cancer cells.