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SOCS-3基因在Balb/c小鼠脑组织中的表达与脑不对称性
引用本文:赵丽纯,苏芸,李康生.SOCS-3基因在Balb/c小鼠脑组织中的表达与脑不对称性[J].生物化学与生物物理进展,2004,31(8):727-730.
作者姓名:赵丽纯  苏芸  李康生
作者单位:汕头大学医学院微生物学与免疫学教研室,汕头,515031
基金项目:国家自然科学基金资助项目(30271211和30371315)和汕头大学研究与发展基金资助项目(L00011).
摘    要:为探讨细胞因子信号传导抑制因子-3(suppresso of cytokine signaling-3, SOCS-3)在Balb/c小鼠皮层、海马、下丘脑中的表达及其与脑不对称性的关系.通过伸爪取食法将Balb/c小鼠分为左利组和右利组,取左、右侧皮层,左、右侧海马及下丘脑,以RT-PCR法间接测定SOCS-3 mRNA水平.结果表明:a.在左利鼠右侧皮层中,SOCS-3基因表达水平显著高于左侧皮层(P<0.05);右利鼠左侧皮层SOCS-3表达显著高于左利鼠左侧皮层(P<0.05).b.海马中SOCS-3表达:左利鼠右侧海马SOCS-3表达显著高于左侧海马(P<0.05);右利鼠左侧海马SOCS-3表达显著高于左利鼠左侧海马(P<0.05).c.右利鼠下丘脑中SOCS-3显著高于左利鼠(P<0.05).上述研究结果提示,Balb/c小鼠脑中SOCS-3表达与脑不对称性有关.

关 键 词:SOCS-3,脑不对称,神经免疫内分泌
收稿时间:2004/2/17 0:00:00
修稿时间:2004/3/28 0:00:00

The Heterogeneity of SOCS-3 in The Brain of Balb/c Mice and Brain Lateralization
ZHAO Li-Chun,SU Yun and LI Kang-Sheng.The Heterogeneity of SOCS-3 in The Brain of Balb/c Mice and Brain Lateralization[J].Progress In Biochemistry and Biophysics,2004,31(8):727-730.
Authors:ZHAO Li-Chun  SU Yun and LI Kang-Sheng
Institution:Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515031, China;Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515031, China;Department of Microbiology and Immunology, Shantou University Medical College, Shantou 515031, China
Abstract:To investigate the expression of suppressor of cytokine signaling 3(SOCS-3)in Balb/c mice brain and the association with brain lateralization, the paw preference test was used to select right-pawed, left-pawed mice. The SOCS-3 expression level was detected by RT-PCR. The results showed that,(1)The SOCS-3 expression level in right cortex was higher than that in left cortex of left-pawed mice (P<0.05) and it was also higher in the left cortex of right-pawed mice than that in the left cortex of left-pawed mice(P<0.05),(2)The SOCS-3 expression level in right hippocampus was higher than that in the left hippocampus of left-pawed mice (P<0.05) and it was also higher in the left hippocampus of right-pawed mice than that in the left hippocampus of left-pawed mice(P<0.05),(3)The SOCS-3 expression level in hypothalamus of right-pawed mice was higher than that of the left-pawed mice (P<0.05). These results indicate that the SOCS-3 expression level in Balb/c mice brain is associated with brain lateralization.
Keywords:SOCS-3  brain lateralization  neuroimmunoendocrinology
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