| p185蛋白及其抗体的研究进展 |
| |
| 引用本文： | 王琛,刘兢.p185蛋白及其抗体的研究进展[J].生物化学与生物物理进展,1999,26(4):347-350. |
| |
| 作者姓名： | 王琛 刘兢 |
| |
| 作者单位： | 中国科学技术大学生命科学学院,合肥,230027 |
| |
| 摘 要： | 描述了p185在信号转导过程中的功能，讨论了抗p185抗体的蛋白质工程及它们在肿瘤治疗中的应用.
|
| 关 键 词： | p185neu/c-erbB-2，信号转导，预后，肿瘤治疗 |
| 收稿时间： | 1998/6/15 0:00:00 |
| 修稿时间： | : 1998-06- |
Advances in Research of p185 Protein and Its Antibodies |
| |
| WANG Chen and LIU Jing.Advances in Research of p185 Protein and Its Antibodies[J].Progress In Biochemistry and Biophysics,1999,26(4):347-350. |
| |
| Authors: | WANG Chen and LIU Jing |
| |
| Institution: | School of Life Sciences, University of Science and Technology of China, Hefei 230027, China;School of Life Sciences, University of Science and Technology of China, Hefei 230027, China |
| |
| Abstract: | p185neu/c-erbB-2 is a receptor tyrosine kinase. It's overexpressed in some adenocarcinomas, such as breast cancer and ovary cancer. It not only plays an important prognostic role, but also acts as a therapeutic target in breast cancer. Its function in signal tranduction is described. The protein engineering of antibodies against p185 and their application in cancer therapy is also discussed. |
| |
| Keywords: | p185 signal tranduction prognostic cancer therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
