| RAC1活化介导的EMT途径对SKOV3细胞顺铂耐药的影响 |
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| 引用本文： | 曾勇,夏昆.RAC1活化介导的EMT途径对SKOV3细胞顺铂耐药的影响[J].生物化学与生物物理进展,2015,42(2):195-196. |
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| 作者姓名： | 曾勇 夏昆 |
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| 作者单位： | 中南大学生命科学学院医学遗传学国家重点实验室；湖南省肿瘤医院转化医学中心,中南大学生命科学学院医学遗传学国家重点实验室 |
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| 基金项目： | 国家自然科学基金（81201730）；中国博士后科学基金（2012M521565）；National Basic Research Program of China (2012CB517902),National Natural Science Foundation of China (81330027) |
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| 摘 要： | <正>Dear Editor,The incidence rate of epithelial ovarian cancers ranks third among female reproductive system cancers,and its mortality rate stands first among the list of gynecologic tumors.The standard mode of treatment is cytoreductive surgery(debulking)plus the administration of platinum-based chemotherapy drugs.About 70%of advanced patients who receive standard treatments can achieve clinical remission.However,a
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| 关 键 词： | administration SKOV3细胞 remission RAC1 EMT stands ranks mortality platinum chemotherapy |
| 收稿时间： | 1/4/2015 12:00:00 AM |
| 修稿时间： | 2015/1/31 0:00:00 |
Chemoresistance to CDDP Induces EMT Through Activation of RAC1 in SKOV3 Human Ovarian Cancer Cells |
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| ZENG Yong and XIA Kun.Chemoresistance to CDDP Induces EMT Through Activation of RAC1 in SKOV3 Human Ovarian Cancer Cells[J].Progress In Biochemistry and Biophysics,2015,42(2):195-196. |
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| Authors: | ZENG Yong and XIA Kun |
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| Institution: | The State Key Laboratory of Medical Genetics,School of Life Sciences, Central South University, Changsha 410005, China; Translational Medicine Research Center of Hunan Cancer Hospital, Changsha 410013, China and The State Key Laboratory of Medical Genetics,School of Life Sciences, Central South University, Changsha 410005, China |
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| Abstract: | The incidence rate of epithelial ovarian cancers ranks third among female reproductive system cancers, and its mortality rate stands first among the list of gynecologic tumors. The standard mode of treatment is cytoreductive surgery (debulking) plus the administration of platinum-based chemotherapy drugs. About 70% of advanced patients who receive standard treatments can achieve clinical remission. However, a certain percentage of patients with clinical remission will still experience tumor recurrence, metastasis, and drug resistance. this study focuses on the occurrence process of EMT in SKOV3 cells, which is mediated by RAC1 activation, as well as the relationship between the process of cell sensitivity and cisplatin (CDDP), and the ability of invasion and metastasis. |
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| Keywords: | activation of RAC1 EMT Chemoresistance |
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