| 中医药的抗炎机制在治疗肝纤维化中的作用 |
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| 引用本文： | 李博,冯文韬,李静祎,李天媚,曹艳璐,吕芳,戴荣继,邓玉林.中医药的抗炎机制在治疗肝纤维化中的作用[J].生物化学与生物物理进展,2020,47(8):790-808. |
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| 作者姓名： | 李博 冯文韬 李静祎 李天媚 曹艳璐 吕芳 戴荣继 邓玉林 |
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| 作者单位： | 北京理工大学生命学院生物医药成分分离与分析北京市重点实验室;北京理工大学前沿交叉科学研究院,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室 |
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| 摘 要： | 肝脏是人体腹腔内最大的实体器官，对维持机体的基本生理功能起着至关重要的作用。肝脏疾病是威胁人类健康的常见病多发病。全球约有10%人口受到不同程度的肝脏疾病的危害，其中，肝纤维化往往成为这些疾病的晚期病理特征。由于肝纤维化的发病机制复杂，尚无有效的合成类药物能够治疗肝纤维化。中药治疗肝纤维化具有多靶点和副作用小的优势。本文综述了肝纤维化的病理特征与诱发炎症的关系，讨论了中药治疗肝纤维化的单味中药、传统配方及其化学活性成分的抗炎症机制。
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| 关 键 词： | 肝纤维化，传统中医药，抗炎治疗，作用机制 |
| 收稿时间： | 2020/6/8 0:00:00 |
| 修稿时间： | 2020/6/8 0:00:00 |
Treatment of Liver Fibrosis using Traditional Chinese Medicine through Anti-inflammatory Mechanism |
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| LI Bo,FENG Wen-Tao,LI Jing-Yi,LI Tian-Mei,CAO Yan-Lu,LV Fang,DAI Rong-Ji and DENG Yu-Lin.Treatment of Liver Fibrosis using Traditional Chinese Medicine through Anti-inflammatory Mechanism[J].Progress In Biochemistry and Biophysics,2020,47(8):790-808. |
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| Authors: | LI Bo FENG Wen-Tao LI Jing-Yi LI Tian-Mei CAO Yan-Lu LV Fang DAI Rong-Ji and DENG Yu-Lin |
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| Institution: | Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology; Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology |
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| Abstract: | Liver is the largest substantial organ in the abdominal cavity and it provides an essential role in maintaining the basic physiological functions. Liver diseases have become one of the common and frequently-occurring diseases that affect 10% of the population worldwide, usually with liver fibrosis as the late stage pathological characteristic. Due to the complexity of pathogenesis, there is no effective synthetic drug to treat liver fibrosis up to date. Traditional Chinese medicine (TCM) has the advantages of multiple targets and small side effects in the treatment of liver fibrosis. This article reviews the pathological mechanism of liver fibrosis and its relationship with inflammation. The application of the active herbal ingredients in TCM, medicinal plants and traditional Chinese formulae to treat liver fibrosis, and their mechanisms of action to inhibit inflammation associated with liver fibrosis are also discussed. |
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| Keywords: | Liver Fibrosis Traditional Chinese Medicine Anti-inflammation Treatment Mechanism of Action |
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