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| 类泛素化修饰Neddylation的功能和调控机制研究进展 | |
| 引用本文： | 何珊,张令强,贺福初.类泛素化修饰Neddylation的功能和调控机制研究进展[J].生物化学与生物物理进展,2009,36(9):1089-1094. |
| 作者姓名： | 何珊 张令强 贺福初 |
| 作者单位： | 1. 北京工业大学生命科学与生物工程学院,北京,100124;军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,北京,100850 2. 军事医学科学院放射与辐射医学研究所,蛋白质组学国家重点实验室,北京,100850 3. 国科学院福建物质结构研究所结构化学国家重点实验室,福州,350002 |
| 基金项目： | 国家自然科学基金资助项目(30830029)和重大科学研究计划课题(2007CB914601, 2009CB918402)部分资助项目 |
| 摘 要： | NEDD8 (neural precursor cell-expressed developmentally downregulated 8) 分子是一类结构上与泛素相似的分子，参与蛋白质翻译后修饰，这一过程被称为Neddylation．Neddylation的发生机制与泛素化相似，需要E1、E2、E3介导的一系列酶促反应．Neddylation修饰在Cullin-Roc类泛素连接酶的活性调控中具有至关重要的作用，与泛素化研究相比，在真核细胞内仅发现了很少的能被Neddylation修饰的底物，Neddylation的生理功能也有待深入研究． |
| 关 键 词： | 蛋白质翻译后修饰，Neddylation，NEDD8，Cullin |
| 收稿时间： | 2009/2/13 0:00:00 |
| 修稿时间： | 2009/5/11 0:00:00 |
Progress in Function and Regulation of Protein Neddylation |
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| HE Shan,ZHANG Ling-Qiang and HE Fu-Chu.Progress in Function and Regulation of Protein Neddylation[J].Progress In Biochemistry and Biophysics,2009,36(9):1089-1094. | |
| Authors: | HE Shan ZHANG Ling-Qiang and HE Fu-Chu |
| Institution: | College of Life Science of Bio-engineering, Beijing University of Technology, Beijing 100124;State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850;State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850;State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850 |
| Abstract: | NEDD8 is a member of the ubiquitin-like proteins. The overall structure of NEDD8 is quite similar to ubiquitin. Covalent conjugation of NEDD8 to proteins at the post-translational level is called Neddylation. Neddylation occurs similarly to ubiquitination and need enzyme cascades involving E1, E2 and E3. Neddylation has been demonstrated to be essential to maintain the ubiquitin ligase activity of Cullin-Roc based E3 ligases. Compared with the ubiquitination which was widely studied in the past two decades, few substrates were identified for Neddylation and the physiological functions of Neddylation need further investigations. The current progress of function and regulation of protein Neddylation will be reviewed. |
| Keywords: | protein translational modification Neddylation NEDD8 Cullin |
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