| 线虫prg-1基因对小RNA表达的影响 |
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| 引用本文： | 黄大卫,崔东亚,王佳佳,何顺民,张鹏.线虫prg-1基因对小RNA表达的影响[J].生物化学与生物物理进展,2016,43(3):265-270. |
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| 作者姓名： | 黄大卫 崔东亚 王佳佳 何顺民 张鹏 |
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| 作者单位： | 河北大学生命科学学院，保定 071000；中国科学院动物研究所系统与进化重点实验室，北京 100101,河北大学生命科学学院，保定 071000；中国科学院动物研究所系统与进化重点实验室，北京 100101；运城学院生命科学系，运城 044000,河北大学生命科学学院，保定 071000；中国科学院动物研究所系统与进化重点实验室，北京 100101,中国科学院动物研究所系统与进化重点实验室，北京 100101,中国科学院动物研究所系统与进化重点实验室，北京 100101 |
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| 摘 要： | 以秀丽隐杆线虫为材料发现，prg-1基因突变不仅影响piRNA的表达，还影响部分miRNA的表达，同时还发现ncRNA-like型小RNA，对ncRNA-like序列比较，认为ncRNA-like与piRNA或miRNA序列极为相似；对ncRNA-like与miRNA或piRNA的基因座比较，发现ncRNA-like与miRNA或piRNA基因座完全相同．推测这些ncRNA-like型小RNA可能与miRNA或piRNA有着相同的RNA前体来源．
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| 关 键 词： | 秀丽隐杆线虫，prg-1，小RNA，表达 |
| 收稿时间： | 2015/9/28 0:00:00 |
| 修稿时间： | 2016/1/28 0:00:00 |
The Effect of prg-1 on Small RNAs Expression of Caenorhabditis elegans |
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| HUANG Da-Wei,CUI Dong-Y,WANG Jia-Ji,HE Shun-Min and ZHANG Peng.The Effect of prg-1 on Small RNAs Expression of Caenorhabditis elegans[J].Progress In Biochemistry and Biophysics,2016,43(3):265-270. |
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| Authors: | HUANG Da-Wei CUI Dong-Y WANG Jia-Ji HE Shun-Min and ZHANG Peng |
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| Institution: | College of Life Science, Hebei University, Baoding 071002, China; Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China,College of Life Science, Hebei University, Baoding 071002, China; Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; College of Life Science, Yuncheng University, Yuncheng 044000, China,College of Life Science, Hebei University, Baoding 071002, China; Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China,Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China and Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | In Caenorhabditis elegans, the expression of all piRNAs, small of miRNAs were influenced by the mutation of prg-1. Especially, some ncRNA-like, a kinds of small RNA, were found in C. elegans. The ncRNA-like had the similar sequence with piRNAs or miRNAs. The results of the analysis in the gene sites between the ncRNA-like and piRNAs or between ncRNA-like and miRNAs, showed that ncRNA-like had the same gene sites with piRNAs or miRNAs. All of these showed that the ncRNA-like were a kind of small RNA and may be processed from the RNA precursor same to piRNAs or miRNAs. |
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| Keywords: | Caenorhabditis elegans prg-1 small RNAs expression |
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