Interaction of the protein C activation peptide with platelets |
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Authors: | Martínez-Cruz Ruth Canseco María Del S Pina Lopez-Martínez Jael Cruz Pedro A Hernández Pérez-Campos Eduardo Cruz Margarito Martínez Alva Félix Córdoba Majluf-Cruz Abraham Zenteno Edgar Ruiz-Argüelles Alejandro |
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Institution: | Centro de Investigación en Ciencias Médicas y Biológicas, Facultad de Medicina y Cirugía, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, México. |
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Abstract: | The peptide NH(2)-DTEDQEDQVDPR-COOH is released during activation of protein C zymogen. We measured the effect of a synthetic peptide with an amino acid sequence similar to that of the natural peptide on platelets from healthy individuals using platelet aggregometry. We found that this synthetic peptide inhibits platelet aggregation induced by thrombin; furthermore, it diminishes mobilization of intraplatelet calcium. Molecular docking showed weak interaction between the synthetic peptide and thrombin. Our findings suggest that this synthetic peptide may interact with a receptor located on the platelet cell membrane. |
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