The CD11a partner in Sus scrofa lymphocyte function-associated antigen-1 (LFA-1): mRNA cloning, structure analysis and comparison with mammalian homologues |
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| Authors: | Philippe GAC Vanden Bergh Thomas Fett Laurent LM Zecchinon Anne VT Thomas and Daniel JM Desmecht |
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| Institution: | (1) Pathology Department, Faculty of Veterinary Medicine, University of Liege, Colonster Boulevard 20 B43, B-4000 Liege, Belgium |
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| Abstract: | Background Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alphaLbeta2), the most abundant and widely expressed beta2-integrin,
is required for many cellular adhesive interactions during the immune response. Many studies have shown that LFA-1 is centrally
involved in the pathogenesis of several diseases caused by Repeats-in-toxin (RTX) -producing bacteria. |
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