Atypical scrapie in sheep from a UK research flock which is free from classical scrapie |
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| Authors: | Hugh A Simmons Marion M Simmons Yvonne I Spencer Melanie J Chaplin Gill Povey Andrew Davis Angel Ortiz-Pelaez Nora Hunter Danny Matthews Anthony E Wrathall |
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| Institution: | (1) Villanueva del Pardillo, Madrid, Horsepital SL, Spain;(2) Department of Biochemistry and Molecular Biology, Medical School, University Complutense of Madrid, 28040, Ciudad Universitaria s/n, Madrid, Spain;(3) Department of Animal Medicine and Surgery, Veterinary School, University Complutense of Madrid, 28040, Ciudad Universitaria s/n, Madrid, Spain |
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| Abstract: | Background Colic could be accompanied by changes in the morphology and physiology of organs and tissues, such as the intestine. This
process might be, at least in part, due to the accumulation of oxidative damage induced by reactive oxygen (ROS) and reactive
nitrogen species (RNS), secondary to intestinal ischemia. Glutathione (GSH), being the major intracellular thiol, provides
protection against oxidative injury. The aim of this study was to investigate whether ischemia-induced intestinal injury could
be related with alterations in GSH metabolism. |
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