Aqueous Fraction of Beta vulgaris Ameliorates Hyperglycemia in Diabetic Mice due to Enhanced Glucose Stimulated Insulin Secretion,Mediated by Acetylcholine and GLP-1, and Elevated Glucose Uptake via Increased Membrane Bound GLUT4 Transporters |
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| Authors: | Ashraf Ul Kabir Mehdi Bin Samad Arif Ahmed Mohammad Rajib Jahan Farjana Akhter Jinat Tasnim S M Nageeb Hasan Sania Sarker Sayfe J M A Hannan |
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| Institution: | 1Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh;2Pharmacy Discipline, Life Science School, Khulna University, Khulna, Bangladesh;Consiglio Nazionale delle Ricerche, ITALY |
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| Abstract: | BackgroundThe study was designed to investigate the probable mechanisms of anti-hyperglycemic activity of B. Vulgaris.ConclusionFindings of the present study clearly prove the role of Acetylcholine and GLP-1 in the Insulin secreting activity of B. Vulgaris. Increased glucose uptake in the skeletal muscles and subsequent glycogen synthesis may also play a part in the anti-hyperglycemic activity of B. Vulgaris. |
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