Risk of Chromosomal Abnormalities in Early Spontaneous Abortion after Assisted Reproductive Technology: A Meta-Analysis |
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Authors: | Jun-Zhen Qin Li-Hong Pang Min-Qing Li Jing Xu Xing Zhou |
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Institution: | 1. Department of Obstetrics and Gynecology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.; 2. Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.; 3. Department of Respiratory Medicine, Third People of Guangxi Zhuang Autonomous Region, Nanning, China.; University of Nevada School of Medicine, United States of America, |
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Abstract: | BackgroundStudies on the risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology (ART) are relatively controversial and insufficient. Thus, to obtain a more precise evaluation of the risk of embryonic chromosomal abnormalities in first-trimester miscarriage after ART, we performed a meta-analysis of all available case–control studies relating to the cytogenetic analysis of chromosomal abnormalities in first-trimester miscarriage after ART.MethodsLiterature search in the electronic databases MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) based on the established strategy. Meta-regression, subgroup analysis, and Galbraith plots were conducted to explore the sources of heterogeneity.ResultsA total of 15 studies with 1,896 cases and 1,186 controls relevant to the risk of chromosomal abnormalities in first- trimester miscarriage after ART, and 8 studies with 601 cases and 602 controls evaluating frequency of chromosome anomaly for maternal age≥35 versus <35 were eligible for the meta-analysis. No statistical difference was found in risk of chromosomally abnormal miscarriage compared to natural conception and the different types of ART utilized, whereas the risk of fetal aneuploidy significantly increased with maternal age≥35 (OR 2.88, 95% CI: 1.74–4.77).ConclusionsART treatment does not present an increased risk for chromosomal abnormalities occurring in a first trimester miscarriage, but incidence of fetal aneuploidy could increase significantly with advancing maternal age. |
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