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Natural Killer Cells Promote Long-Term Hepatobiliary Inflammation in a Low-Dose Rotavirus Model of Experimental Biliary Atresia |
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| Authors: | James E Squires Pranavkumar Shivakumar Reena Mourya Kazuhiko Bessho Stephanie Walters Jorge A Bezerra |
| Institution: | 1Department of Pediatrics of the University of Cincinnati College of Medicine, the Division of Gastroenterology, Hepatology and Nutrition and the Pediatric Liver Care Center of Cincinnati Children’s Hospital Medical Center; Cincinnati, Ohio, United States of America;2Division of Pediatrics, Osaka University, Osaka, Japan;Texas A&M Health Science Center, UNITED STATES |
| Abstract: | ConclusionsLower inoculation of RRV-induced progressive liver injury and fibrosis via NK cells. These findings point to the potential use of NK cell-depleting strategies to block progression of liver disease in biliary atresia. |
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