A novel role for CD55 in granulocyte homeostasis and anti-bacterial host defense |
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Authors: | Veninga Henrike Hoek Robert M de Vos Alex F de Bruin Alex M An Feng-Qi van der Poll Tom van Lier René A W Medof M Edward Hamann Jörg |
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Institution: | 1Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;2Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;3Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America;Centre de Recherche Public de la Santé (CRP-Santé), Luxembourg |
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Abstract: | BackgroundIn addition to its complement-regulating activity, CD55 is a ligand of the adhesion class G protein-coupled receptor CD97; however, the relevance of this interaction has remained elusive. We previously showed that mice lacking a functional CD97 gene have increased numbers of granulocytes.Methodology/ResultsHere, we demonstrate that CD55-deficient mice display a comparable phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen. This granulocytosis was independent of increased complement activity. Augmented numbers of Gr-1-positive cells in cell cycle in the bone marrow indicated a higher granulopoietic activity in mice lacking either CD55 or CD97. Concomitant with the increase in blood granulocyte numbers, Cd55
-/- mice challenged with the respiratory pathogen Streptococcus pneumoniae developed less bacteremia and died later after infection.ConclusionsCollectively, these data suggest that complement-independent interaction of CD55 with CD97 is functionally relevant and involved in granulocyte homeostasis and host defense. |
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