The Use of Biatain Ag in Hard-to-Heal Venous Leg Ulcers: Meta-Analysis of Randomised Controlled Trials |
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| Authors: | David Leaper Christian Münter Sylvie Meaume Alessandro Scalise Nacho Blanes Mompó Birte Petersen Jakobsen Finn Gottrup |
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| Institution: | 1. Wound Healing Research Unit, Cardiff University, Cardiff, United Kingdom.; 2. General Practitioner, Hamburg, Germany.; 3. Hôpital Rothschild, Paris, France.; 4. Ancona Politechnical University, Faculty of Medicine, Ancona, Italy.; 5. Hospital de Manises, Valencia, Spain.; 6. Coloplast A/S, Humlebaek, Denmark.; 7. Copenhagen Wound Healing Center, Bispebjerg University Hospital, Copenhagen, Denmark.; University Hospital Hamburg-Eppendorf, Germany, |
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| Abstract: | BackgroundVenous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs).AimTo evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing.Patients and Methods685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis.ResultsBiatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002).ConclusionThe meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers. |
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