Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication |
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| Authors: | Yoshimasa Saito Hidekazu Suzuki Hitoshi Tsugawa Hiroyuki Imaeda Juntaro Matsuzaki Kenro Hirata Naoki Hosoe Masahiko Nakamura Makio Mukai Hidetsugu Saito Toshifumi Hibi |
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| Institution: | 1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Shinjuku-ku, Tokyo, Japan.; 2. Department of Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.; 3. School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.; 4. Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo, Japan.; Queen Elizabeth Hospital, Hong Kong, |
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| Abstract: | microRNAs (miRNAs) are small non-coding RNAs that can function as endogenous silencers of target genes and play critical roles in human malignancies. To investigate the molecular pathogenesis of gastric mucosa-associated lymphoid tissue (MALT) lymphoma, the miRNA expression profile was analyzed. miRNA microarray analysis with tissue specimens from gastric MALT lymphomas and surrounding non-tumor mucosae revealed that a hematopoietic-specific miRNA miR-142 and an oncogenic miRNA miR-155 were overexpressed in MALT lymphoma lesions. The expression levels of miR-142-5p and miR-155 were significantly increased in MALT lymphomas which do not respond to Helicobacter pylori (H. pylori) eradication. The expression levels of miR-142-5p and miR-155 were associated with the clinical courses of gastric MALT lymphoma cases. Overexpression of miR-142-5p and miR-155 was also observed in Helicobacter heilmannii-infected C57BL/6 mice, an animal model of gastric MALT lymphoma. In addition, miR-142-5p and miR-155 suppress the proapoptotic gene TP53INP1 as their target. The results of this study indicate that overexpression of miR-142-5p and miR-155 plays a critical role in the pathogenesis of gastric MALT lymphoma. These miRNAs might have potential application as therapeutic targets and novel biomarkers for gastric MALT lymphoma. |
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