Serum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentina |
| |
Authors: | Patrycja A Naesgaard Ricardo A León De La Fuente Stein Tore Nilsen Leik Woie Torbjoern Aarsland Cato Brede Harry Staines Dennis W T Nilsen |
| |
Institution: | Department of Cardiology, Stavanger University Hospital, Stavanger, Norway. |
| |
Abstract: | BackgroundSeveral studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D 25(OH)D] in serum.MethodsWe assessed the prognostic utility of 25(OH)D in 982 chest-pain patients with suspected acute coronary syndrome (ACS) from Salta, Northern Argentina. 2-year follow-up data including all-cause mortality, cardiac death and sudden cardiac death were analyzed in quartiles of 25(OH)D, applying univariate and multivariate analysis.ResultsThere were statistically significant changes in seasonal 25(OH)D levels. At follow-up, 119 patients had died. The mean 25(OH)D levels were significantly lower among patients dying than in long-term survivors, both in the total population and in patients with a troponin T (TnT) release (n?=?388). When comparing 25(OH)D in the highest quartile to the lowest quartile in a multivariable Cox regression model for all-cause mortality, the hazard ratio (HR) for cardiac death and sudden cardiac death in the total population was 0.37 (95% CI, 0.19–0.73), p?=?0.004, 0.23 (95% CI, 0.08–0.67), p?=?0.007, and 0.32 (95% CI, 0.11–0.94), p?=?0.038, respectively. In patients with TnT release, the respective HR was 0.24 (95% CI, 0.10–0.54), p?=?0.001, 0.18 (95% CI, 0.05–0.60), p?=?0.006 and 0.25 (95% CI, 0.07–0.89), p?=?0.033. 25(OH)D had no prognostic value in patients with no TnT release.ConclusionVitamin D was shown to be a useful biomarker for prediction of mortality when obtained at admission in chest pain patients with suspected ACS.Trial registrationClinicalTrials.gov {"type":"clinical-trial","attrs":{"text":"NCT01377402","term_id":"NCT01377402"}}NCT01377402 |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|