The N-permethylation of chitosan and the preparation of N-trimethyl chitosan iodide |
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Authors: | Riccardo AA Muzzarelli Fabio Tanfani |
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Institution: | Institute of Biochemistry, Faculty of Medicine, University of Ancona, I-60100 Ancona, Italy |
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Abstract: | Chitosan was N-permethylated by reaction with formaldehyde and sodium borohydride under controlled conditions (pH 4·0, 15°C, reaction times 12 and 8 h, respectively). The N-permethylated chitosan was reacted with methyl iodide at 35°C and N-trimethyl chitosan iodide with a quaternary nitrogen degree of 60% was obtained. This material may have uses as an antibiotic and an ion exchange material. |
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