Microspheres of chitosan/carboxymethyl cashew gum (CH/CMCG): Effect of chitosan molar mass and CMCG degree of substitution on the swelling and BSA release |
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| Authors: | Guilherme A Magalhães Clara MW Santos Durcilene A Silva Jeanny S Maciel Judith PA Feitosa Haroldo CB Paula Regina CM de Paula |
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| Institution: | 1. Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 6.021, CEP 60455-760 Fortaleza – Ceará, Brazil;2. Departamento de Química Analítica e Físico Química, Universidade Federal do Ceará, CP 6.021, CEP 60455-760 Fortaleza – Ceará, Brazil |
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| Abstract: | Chitosan/carboxymethyl cashew gum microspheres (CH/CMCG) were prepared with carboxymethyl cashew gum with two different degrees of substitution (DS) and loaded with bovine serum albumin (BSA). In water, for microspheres formed using low molar mass chitosan (LCH) sample swelling was observed for both CMCG samples and CMCG sample with higher DS showed greater swelling. Using high molar mass chitosan (HCH) sample swelling was observed only for microsphere with high DS of CMCG (DS = 0.44). At pH 7.4, the HCH sample led to a lower degree of swelling. The diffusion coefficients Dv were higher for the higher DS of CMCG in both media and the HCH sample had a lower Dv than LCH one. Faster BSA release rates were observed for beads prepared with the higher DS, whereas those prepared with DS = 0.16 took twice the time to reach similar release profiles. All microsphere systems investigated had a non-Fickian BSA release mechanism. |
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