TSLP receptor is not essential for house dust mite-induced allergic rhinitis in mice |
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| Authors: | Wakako Nakanishi Yoshihisa Hiraishi Sachiko Yamaguchi Ayako Takamori Hideaki Morita Kenji Matsumoto Hirohisa Saito Katsuko Sudo Tatsuya Yamasoba Susumu Nakae |
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| Institution: | 1. Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan;2. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;4. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan;5. Animal Research Center, Tokyo Medical University, Tokyo, Japan;6. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama, Japan |
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| Abstract: | TSLP induces Th2 cytokine production by Th2 cells and various other types of cells, thereby contributing to Th2-type immune responses and development of allergic disorders. We found that house dust mite (HDM) extract induced TSLP production by nasal epithelial cells, suggesting that TSLP may be involved in development of HDM-induced allergic rhinitis (AR). To investigate that possibility in greater detail, wild-type and TSLP receptor-deficient (TSLPR?/?) mice on the C57BL/6J background were repeatedly treated intranasally with HDM extract. The frequency of sneezing, numbers of eosinophils and goblet cells, thickness of submucosal layers, serum levels of total IgE and HDM-specific IgG1, and levels of IL-4, IL-5 and IL-13 in the culture supernatants of HDM-stimulated LN cells were comparable in the two mouse strains. Those findings indicate that, in mice, TSLPR is not crucial for development of HDM-induced AR. |
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| Keywords: | TSLP receptor Allergy Mouse Rhinitis House dust mite |
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