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Structural and functional link between the mitochondrial network and the endoplasmic reticulum
Authors:Carlotta Giorgi  Diego De Stefani  Angela Bononi  Rosario Rizzuto  Paolo Pinton  
Institution:1. Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI) and Emilia Romagna Laboratory BioPharmaNet, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy;2. Vita-Salute San Raffaele University, Center of Excellence in Cell Development, and IIT Network, Research Unit of Molecular Neuroscience, Via Olgettina 58, 20132 Milan, Italy;3. Department of Biomedical Sciences, University of Padua, Via G. Colombo 3, 35100 Padua, Italy;1. Medical Research Council, Mitochondrial Biology Unit, University of Cambridge, Wellcome Trust/MRC building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK;2. Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada;1. Department of Biomedical Sciences, University of Padova, Italy;2. Neuroscience Institute, National Research Council (CNR), Padova, Italy;1. Department of Biomedical Sciences, University of Padua, Padua, Italy;2. INSERM UMR-1060, CarMeN Laboratory, Lyon 1 University, INRA U1397, F-69921 Oullins, France;1. Dept. of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy;2. Neonatal Intensive Care Unit, University Hospital S. Anna Ferrara, 44124 Ferrara, Italy;3. Dept. of Clinical and Molecular Sciences, Polytechnical University of Marche, 60126 Ancona, Italy;4. Nencki Institute of Experimental Biology, 02-093 Warsaw, Poland;5. Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy;1. INSERM UMR-1060, CarMeN Laboratory, Lyon 1 University, INRA U1235, INSA of Lyon, Rockefeller and Charles-Merieux Lyon-Sud medical Universities, 69003 Lyon, France;2. Endocrinology, diabetology and nutrition service, Lyon-Sud Hospital, Hospices Civils de Lyon, 69310 Pierre-Bénite, France
Abstract:Mitochondrial and endoplasmic reticulum (ER) networks are fundamental for the maintenance of cellular homeostasis and for determination of cell fate under stress conditions. Recent structural and functional studies revealed the interaction of these networks. These zones of close contact between ER and mitochondria called MAM (mitochondria associated membranes) support communication between the two organelles including bioenergetics and cell survival. The existence of macromolecular complexes in these contact sites has also been revealed. In this contribution, we will review: (i) the ER and mitochondria structure and their dynamics, (ii) the basic principles of ER mitochondrial Ca2+ transport, (iii) the physiological/pathological role of this cross-talk.
Keywords:ER: endoplasmic reticulum  Mitochondria  MAM: mitochondria associated membranes  Calcium  ER stress  Apoptosis
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