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Resistoflavine, cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN1/7 |
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| Authors: | Gorajana Adinarayana Venkatesan M Vinjamuri Saisha Kurada Bapiraju V V S N Peela Sujatha Jangam Premkumar Poluri Ellaiah Zeeck Axel |
| Institution: | aSchool of Pharmacy, International Medical University, Sesama Center, Plaza, Komanwel, Bukit jalil, 57000 Kuala Lumpur, Malaysia bInstitut fur Organische Chemie, George-August Universitat, Tammannstrasse 2, D-37077 Gottingen, Germany cBiotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India |
| Abstract: | In our systematic screening programme for marine actinomycetes, a bioactive Streptomycete was isolated from marine sediment samples of Bay of Bengal, India. The taxonomic studies indicated that the isolate belongs to Streptomyces chibaensis and it was designated as S. chibaensis AUBN1/7. The isolate yielded a cytotoxic compound. It was obtained by solvent extraction followed by the chromatographic purification. Based on the spectral data of the pure compound, it was identified as quinone-related antibiotic, resistoflavine (1). It showed a potent cytotoxic activity against cell lines viz. HMO2 (Gastric adenocarcinoma) and HePG2 (Hepatic carcinoma) in vitro and also exhibited weak antibacterial activities against Gram-positive and Gram-negative bacteria. |
| Keywords: | Streptomyces Cytotoxic compound Antibacterial activity Quinone Resistoflavine |
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